Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Philipp A. Ilinykh; Kai Huang; Rodrigo I. Santos; Pavlo Gilchuk; Bronwyn M. Gunn; Marcus M. Karim; Jenny Liang; Mallorie E. Fouch; Edgar Davidson; Diptiben V. Parekh; James Kimble; Colette A. Pietzsch; Michelle Meyer; Natalia A. Kuzmina; Larry Zeitlin; Erica Ollmann Saphire; Galit Alter; James E. Crowe; Alexander Bukreyev

doi:10.1016/j.chom.2020.03.025

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Philipp A. Ilinykh
, Kai Huang
, Rodrigo I. Santos
, Pavlo Gilchuk
, Bronwyn M. Gunn
, Marcus M. Karim
, Jenny Liang
, Mallorie E. Fouch
, Edgar Davidson
, Diptiben V. Parekh
, James Kimble
, Colette A. Pietzsch
, Michelle Meyer
, Natalia A. Kuzmina
, Larry Zeitlin
, Erica Ollmann Saphire
, Galit Alter
, James E. Crowe
, Alexander Bukreyev

Pathology

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.

Original language	English (US)
Pages (from-to)	976-991.e11
Journal	Cell Host and Microbe
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2020.03.025
State	Published - Jun 10 2020

Keywords

Fc-mediated protective effects
Marburg virus
animal models of filovirus infection
antibodies
cooperativity of antibody binding
glycoprotein

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

Access to Document

10.1016/j.chom.2020.03.025

Cite this

Ilinykh, P. A., Huang, K., Santos, R. I., Gilchuk, P., Gunn, B. M., Karim, M. M., Liang, J., Fouch, M. E., Davidson, E., Parekh, D. V., Kimble, J., Pietzsch, C. A., Meyer, M., Kuzmina, N. A., Zeitlin, L., Saphire, E. O., Alter, G., Crowe, J. E., & Bukreyev, A. (2020). Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. Cell Host and Microbe, 27(6), 976-991.e11. https://doi.org/10.1016/j.chom.2020.03.025

Ilinykh, PA, Huang, K, Santos, RI, Gilchuk, P, Gunn, BM, Karim, MM, Liang, J, Fouch, ME, Davidson, E, Parekh, DV, Kimble, J, Pietzsch, CA, Meyer, M, Kuzmina, NA, Zeitlin, L, Saphire, EO, Alter, G, Crowe, JE & Bukreyev, A 2020, 'Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies', Cell Host and Microbe, vol. 27, no. 6, pp. 976-991.e11. https://doi.org/10.1016/j.chom.2020.03.025

@article{714b45dd525144528079a82f1f219933,

title = "Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies",

abstract = "Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.",

keywords = "Fc-mediated protective effects, Marburg virus, animal models of filovirus infection, antibodies, cooperativity of antibody binding, glycoprotein",

author = "Ilinykh, \{Philipp A.\} and Kai Huang and Santos, \{Rodrigo I.\} and Pavlo Gilchuk and Gunn, \{Bronwyn M.\} and Karim, \{Marcus M.\} and Jenny Liang and Fouch, \{Mallorie E.\} and Edgar Davidson and Parekh, \{Diptiben V.\} and James Kimble and Pietzsch, \{Colette A.\} and Michelle Meyer and Kuzmina, \{Natalia A.\} and Larry Zeitlin and Saphire, \{Erica Ollmann\} and Galit Alter and Crowe, \{James E.\} and Alexander Bukreyev",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

day = "10",

doi = "10.1016/j.chom.2020.03.025",

language = "English (US)",

volume = "27",

pages = "976--991.e11",

journal = "Cell Host and Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

AU - Ilinykh, Philipp A.

AU - Huang, Kai

AU - Santos, Rodrigo I.

AU - Gilchuk, Pavlo

AU - Gunn, Bronwyn M.

AU - Karim, Marcus M.

AU - Liang, Jenny

AU - Fouch, Mallorie E.

AU - Davidson, Edgar

AU - Parekh, Diptiben V.

AU - Kimble, James

AU - Pietzsch, Colette A.

AU - Meyer, Michelle

AU - Kuzmina, Natalia A.

AU - Zeitlin, Larry

AU - Saphire, Erica Ollmann

AU - Alter, Galit

AU - Crowe, James E.

AU - Bukreyev, Alexander

PY - 2020/6/10

Y1 - 2020/6/10

N2 - Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.

AB - Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.

KW - Fc-mediated protective effects

KW - Marburg virus

KW - animal models of filovirus infection

KW - antibodies

KW - cooperativity of antibody binding

KW - glycoprotein

UR - https://www.scopus.com/pages/publications/85085884760

UR - https://www.scopus.com/pages/publications/85085884760#tab=citedBy

U2 - 10.1016/j.chom.2020.03.025

DO - 10.1016/j.chom.2020.03.025

M3 - Article

C2 - 32320678

AN - SCOPUS:85085884760

SN - 1931-3128

VL - 27

SP - 976-991.e11

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this