Non-small cell lung cancer and elevated eosinophil count: A case report and literature review

Rohit Venkatesan, Amir Salam, Issam Alawin, Maurice Willis

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    In earlier work it was unclear whether there was any true prognostic value when high numbers of eosinophils were seen in the peripheral blood of lung cancer patients. As time passed, it became somewhat clearer that this occurrence may correlate with a poor prognosis in these patients. These ideas reflected what we came to know about the pathophysiology of hypereosinophilia in the blood in this setting. With paraneoplastic processes and distant metastases (to the bone marrow) thought to function at least in part as the mechanism of hypereosinophilia in these patients, it became more evident why these patients tended to have a poorer prognosis. However interestingly and paradoxically, there also has been work indicating that this occurrence may actually be protective against metastatic disease.Here, we present the case of a sixty year old Caucasian female who presented with non-small cell lung cancer (NSCLC), diffusely metastatic at presentation, who also presented with hypereosinophilia which proved to be a poor prognostic indicator in this case.

    Original languageEnglish (US)
    Pages (from-to)55-58
    Number of pages4
    JournalCancer Treatment Communications
    Volume4
    DOIs
    StatePublished - 2015

    Fingerprint

    Eosinophils
    Non-Small Cell Lung Carcinoma
    Lung Neoplasms
    Bone Marrow
    Neoplasm Metastasis

    Keywords

    • Case report
    • Eosinophils
    • Lung
    • Prognosis

    ASJC Scopus subject areas

    • Oncology

    Cite this

    Non-small cell lung cancer and elevated eosinophil count : A case report and literature review. / Venkatesan, Rohit; Salam, Amir; Alawin, Issam; Willis, Maurice.

    In: Cancer Treatment Communications, Vol. 4, 2015, p. 55-58.

    Research output: Contribution to journalArticle

    Venkatesan, Rohit ; Salam, Amir ; Alawin, Issam ; Willis, Maurice. / Non-small cell lung cancer and elevated eosinophil count : A case report and literature review. In: Cancer Treatment Communications. 2015 ; Vol. 4. pp. 55-58.
    @article{7f1270c2316c4899bf959855e3413780,
    title = "Non-small cell lung cancer and elevated eosinophil count: A case report and literature review",
    abstract = "In earlier work it was unclear whether there was any true prognostic value when high numbers of eosinophils were seen in the peripheral blood of lung cancer patients. As time passed, it became somewhat clearer that this occurrence may correlate with a poor prognosis in these patients. These ideas reflected what we came to know about the pathophysiology of hypereosinophilia in the blood in this setting. With paraneoplastic processes and distant metastases (to the bone marrow) thought to function at least in part as the mechanism of hypereosinophilia in these patients, it became more evident why these patients tended to have a poorer prognosis. However interestingly and paradoxically, there also has been work indicating that this occurrence may actually be protective against metastatic disease.Here, we present the case of a sixty year old Caucasian female who presented with non-small cell lung cancer (NSCLC), diffusely metastatic at presentation, who also presented with hypereosinophilia which proved to be a poor prognostic indicator in this case.",
    keywords = "Case report, Eosinophils, Lung, Prognosis",
    author = "Rohit Venkatesan and Amir Salam and Issam Alawin and Maurice Willis",
    year = "2015",
    doi = "10.1016/j.ctrc.2015.05.002",
    language = "English (US)",
    volume = "4",
    pages = "55--58",
    journal = "Cancer Treatment and Research Communications",
    issn = "2213-0896",
    publisher = "Elsevier Ltd",

    }

    TY - JOUR

    T1 - Non-small cell lung cancer and elevated eosinophil count

    T2 - A case report and literature review

    AU - Venkatesan, Rohit

    AU - Salam, Amir

    AU - Alawin, Issam

    AU - Willis, Maurice

    PY - 2015

    Y1 - 2015

    N2 - In earlier work it was unclear whether there was any true prognostic value when high numbers of eosinophils were seen in the peripheral blood of lung cancer patients. As time passed, it became somewhat clearer that this occurrence may correlate with a poor prognosis in these patients. These ideas reflected what we came to know about the pathophysiology of hypereosinophilia in the blood in this setting. With paraneoplastic processes and distant metastases (to the bone marrow) thought to function at least in part as the mechanism of hypereosinophilia in these patients, it became more evident why these patients tended to have a poorer prognosis. However interestingly and paradoxically, there also has been work indicating that this occurrence may actually be protective against metastatic disease.Here, we present the case of a sixty year old Caucasian female who presented with non-small cell lung cancer (NSCLC), diffusely metastatic at presentation, who also presented with hypereosinophilia which proved to be a poor prognostic indicator in this case.

    AB - In earlier work it was unclear whether there was any true prognostic value when high numbers of eosinophils were seen in the peripheral blood of lung cancer patients. As time passed, it became somewhat clearer that this occurrence may correlate with a poor prognosis in these patients. These ideas reflected what we came to know about the pathophysiology of hypereosinophilia in the blood in this setting. With paraneoplastic processes and distant metastases (to the bone marrow) thought to function at least in part as the mechanism of hypereosinophilia in these patients, it became more evident why these patients tended to have a poorer prognosis. However interestingly and paradoxically, there also has been work indicating that this occurrence may actually be protective against metastatic disease.Here, we present the case of a sixty year old Caucasian female who presented with non-small cell lung cancer (NSCLC), diffusely metastatic at presentation, who also presented with hypereosinophilia which proved to be a poor prognostic indicator in this case.

    KW - Case report

    KW - Eosinophils

    KW - Lung

    KW - Prognosis

    UR - http://www.scopus.com/inward/record.url?scp=84947916892&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84947916892&partnerID=8YFLogxK

    U2 - 10.1016/j.ctrc.2015.05.002

    DO - 10.1016/j.ctrc.2015.05.002

    M3 - Article

    AN - SCOPUS:84947916892

    VL - 4

    SP - 55

    EP - 58

    JO - Cancer Treatment and Research Communications

    JF - Cancer Treatment and Research Communications

    SN - 2213-0896

    ER -