Noncompliance with Medical Treatment: Pseudomalabsorption of Levothyroxine

Mohsen S. Eledrisi, Aleksandra Szymajda, Mohammad Alshanti, Randall Urban

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Euthyroidism could not be achieved in a 41-year-old woman with primary hypothyroidism despite escalating doses of oral levothyroxine as high as 600 μg and 100 μg of triiodothyronine daily. Clinical and biochemical evidence of hypothyroidism persisted even with the administration of intramuscular levothyroxine. There was no history compatible with drug-induced malabsorption of levothyroxine. Evaluation of serum showed no thyroid hormone autoantibodies. After hospitalization, intravenous levothyroxine therapy returned thyroid hormone to normal concentrations. Moreover, thyroid hormone loading tests revealed normal oral absorption of both levothyroxine and triiodothyronine. Noncompliance with medical treatment leading to pseudomalabsorption of levothyroxine should be considered in patients who have persistent hypothyroidism with high-dose replacement therapy.

Original languageEnglish (US)
Pages (from-to)833-836
Number of pages4
JournalSouthern Medical Journal
Volume94
Issue number1-10
StatePublished - Aug 2001
Externally publishedYes

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Thyroxine
Hypothyroidism
Thyroid Hormones
Triiodothyronine
Therapeutics
Autoantibodies
Hospitalization
History
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Eledrisi, M. S., Szymajda, A., Alshanti, M., & Urban, R. (2001). Noncompliance with Medical Treatment: Pseudomalabsorption of Levothyroxine. Southern Medical Journal, 94(1-10), 833-836.

Noncompliance with Medical Treatment : Pseudomalabsorption of Levothyroxine. / Eledrisi, Mohsen S.; Szymajda, Aleksandra; Alshanti, Mohammad; Urban, Randall.

In: Southern Medical Journal, Vol. 94, No. 1-10, 08.2001, p. 833-836.

Research output: Contribution to journalArticle

Eledrisi, MS, Szymajda, A, Alshanti, M & Urban, R 2001, 'Noncompliance with Medical Treatment: Pseudomalabsorption of Levothyroxine', Southern Medical Journal, vol. 94, no. 1-10, pp. 833-836.
Eledrisi, Mohsen S. ; Szymajda, Aleksandra ; Alshanti, Mohammad ; Urban, Randall. / Noncompliance with Medical Treatment : Pseudomalabsorption of Levothyroxine. In: Southern Medical Journal. 2001 ; Vol. 94, No. 1-10. pp. 833-836.
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