Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes

Gregg Milligan, Lorraine Flaherty, Vivian L. Braciale, Thomas J. Braciale

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A large number of class I-like genes are located distal to the K and D regions of the murine major histocompatibility complex (MHC) within the Q and TL region. The function of the molecules encoded within this region is obscure since unlike conventional MHC gene products, these molecules have not been reported to present processed environmental antigens to T cells. In the present report, we demonstrate that a peptide corresponding to processed influenza virus hemagglutinin can be recognized by CD8+ T cell receptor α/β-positive cytotoxic T lymphocytes (CTL) in association with a MHC class I-like product encoded within the TL region. Thus, nonconventional class I MHC molecules can bind and present processed environmental antigens, and TCR-α/β CTL directed to such peptide MHC complexes are represented in the mature T cell pool. Our data imply that Q/TL region products may be charged by peptides generated through an antigen processing and presentation pathway distinct from the pathway used by conventional MHC molecules and not normally available to environmental antigens.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Experimental Medicine
Volume174
Issue number1
StatePublished - 1991
Externally publishedYes

Fingerprint

Viral Antigens
Cytotoxic T-Lymphocytes
Major Histocompatibility Complex
Antigen Presentation
Antigens
Peptides
MHC Class I Genes
T-Lymphocytes
Hemagglutinins
T-Cell Antigen Receptor
Orthomyxoviridae
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes. / Milligan, Gregg; Flaherty, Lorraine; Braciale, Vivian L.; Braciale, Thomas J.

In: Journal of Experimental Medicine, Vol. 174, No. 1, 1991, p. 133-138.

Research output: Contribution to journalArticle

@article{0bc3b1a7cf7840f995d069fed026d374,
title = "Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes",
abstract = "A large number of class I-like genes are located distal to the K and D regions of the murine major histocompatibility complex (MHC) within the Q and TL region. The function of the molecules encoded within this region is obscure since unlike conventional MHC gene products, these molecules have not been reported to present processed environmental antigens to T cells. In the present report, we demonstrate that a peptide corresponding to processed influenza virus hemagglutinin can be recognized by CD8+ T cell receptor α/β-positive cytotoxic T lymphocytes (CTL) in association with a MHC class I-like product encoded within the TL region. Thus, nonconventional class I MHC molecules can bind and present processed environmental antigens, and TCR-α/β CTL directed to such peptide MHC complexes are represented in the mature T cell pool. Our data imply that Q/TL region products may be charged by peptides generated through an antigen processing and presentation pathway distinct from the pathway used by conventional MHC molecules and not normally available to environmental antigens.",
author = "Gregg Milligan and Lorraine Flaherty and Braciale, {Vivian L.} and Braciale, {Thomas J.}",
year = "1991",
language = "English (US)",
volume = "174",
pages = "133--138",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "1",

}

TY - JOUR

T1 - Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes

AU - Milligan, Gregg

AU - Flaherty, Lorraine

AU - Braciale, Vivian L.

AU - Braciale, Thomas J.

PY - 1991

Y1 - 1991

N2 - A large number of class I-like genes are located distal to the K and D regions of the murine major histocompatibility complex (MHC) within the Q and TL region. The function of the molecules encoded within this region is obscure since unlike conventional MHC gene products, these molecules have not been reported to present processed environmental antigens to T cells. In the present report, we demonstrate that a peptide corresponding to processed influenza virus hemagglutinin can be recognized by CD8+ T cell receptor α/β-positive cytotoxic T lymphocytes (CTL) in association with a MHC class I-like product encoded within the TL region. Thus, nonconventional class I MHC molecules can bind and present processed environmental antigens, and TCR-α/β CTL directed to such peptide MHC complexes are represented in the mature T cell pool. Our data imply that Q/TL region products may be charged by peptides generated through an antigen processing and presentation pathway distinct from the pathway used by conventional MHC molecules and not normally available to environmental antigens.

AB - A large number of class I-like genes are located distal to the K and D regions of the murine major histocompatibility complex (MHC) within the Q and TL region. The function of the molecules encoded within this region is obscure since unlike conventional MHC gene products, these molecules have not been reported to present processed environmental antigens to T cells. In the present report, we demonstrate that a peptide corresponding to processed influenza virus hemagglutinin can be recognized by CD8+ T cell receptor α/β-positive cytotoxic T lymphocytes (CTL) in association with a MHC class I-like product encoded within the TL region. Thus, nonconventional class I MHC molecules can bind and present processed environmental antigens, and TCR-α/β CTL directed to such peptide MHC complexes are represented in the mature T cell pool. Our data imply that Q/TL region products may be charged by peptides generated through an antigen processing and presentation pathway distinct from the pathway used by conventional MHC molecules and not normally available to environmental antigens.

UR - http://www.scopus.com/inward/record.url?scp=0025763221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025763221&partnerID=8YFLogxK

M3 - Article

C2 - 1905336

AN - SCOPUS:0025763221

VL - 174

SP - 133

EP - 138

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 1

ER -