Nongenomic signaling pathways of estrogen toxicity

Cheryl S. Watson, Yow Jiun Jeng, Mikhail Y. Kochukov

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Abstract

    Xenoestrogens can affect the healthy functioning of a variety of tissues by acting as potent estrogens via nongenomic signaling pathways or by interfering with those actions of multiple physiological estrogens. Collectively, our and other studies have compared a wide range of estrogenic compounds, including some closely structurally related subgroups. The estrogens that have been studied include environmental contaminants of different subclasses, dietary estrogens, and several prominent physiological metabolites. By comparing the nongenomic signaling and functional responses to these compounds, we have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes that eventually integrate at the level of mitogen-activated protein kinase activities to coordinately regulate broad cellular destinies, such as proliferation, apoptosis, or differentiation.

    Original languageEnglish (US)
    Pages (from-to)1-11
    Number of pages11
    JournalToxicological Sciences
    Volume115
    Issue number1
    DOIs
    StatePublished - May 2010

    Fingerprint

    Toxicity
    Estrogens
    Tissue
    Cell signaling
    Metabolites
    Mitogen-Activated Protein Kinases
    Estrogen Receptors
    Impurities
    Apoptosis
    Membranes

    Keywords

    • Membrane estrogen receptors
    • Signaling
    • Xenoestrogen

    ASJC Scopus subject areas

    • Toxicology
    • Medicine(all)

    Cite this

    Nongenomic signaling pathways of estrogen toxicity. / Watson, Cheryl S.; Jeng, Yow Jiun; Kochukov, Mikhail Y.

    In: Toxicological Sciences, Vol. 115, No. 1, 05.2010, p. 1-11.

    Research output: Contribution to journalArticle

    Watson, CS, Jeng, YJ & Kochukov, MY 2010, 'Nongenomic signaling pathways of estrogen toxicity', Toxicological Sciences, vol. 115, no. 1, pp. 1-11. https://doi.org/10.1093/toxsci/kfp288
    Watson, Cheryl S. ; Jeng, Yow Jiun ; Kochukov, Mikhail Y. / Nongenomic signaling pathways of estrogen toxicity. In: Toxicological Sciences. 2010 ; Vol. 115, No. 1. pp. 1-11.
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