Nongenomic signaling pathways of estrogen toxicity

Cheryl S. Watson, Yow Jiun Jeng, Mikhail Y. Kochukov

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Xenoestrogens can affect the healthy functioning of a variety of tissues by acting as potent estrogens via nongenomic signaling pathways or by interfering with those actions of multiple physiological estrogens. Collectively, our and other studies have compared a wide range of estrogenic compounds, including some closely structurally related subgroups. The estrogens that have been studied include environmental contaminants of different subclasses, dietary estrogens, and several prominent physiological metabolites. By comparing the nongenomic signaling and functional responses to these compounds, we have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes that eventually integrate at the level of mitogen-activated protein kinase activities to coordinately regulate broad cellular destinies, such as proliferation, apoptosis, or differentiation.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalToxicological Sciences
Volume115
Issue number1
DOIs
StatePublished - May 1 2010

Keywords

  • Membrane estrogen receptors
  • Signaling
  • Xenoestrogen

ASJC Scopus subject areas

  • Toxicology

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