Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation

Chad E. Mire, Benjamin A. Satterfield, Thomas W. Geisbert

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Hendra and Nipah viruses are henipaviruses that have caused lethal human disease in Australia and Malaysia, Bangladesh, India, and the Philippines, respectively. These viruses are considered Category C pathogens by the US Centers for Disease Control. Nipah virus was recently placed on the World Health Organization Research and Development Blueprint Roadmaps for vaccine and therapeutic development. Given the infrequent and unpredictable nature of henipavirus outbreaks licensure of vaccines and therapeutics will likely require an animal model to demonstrate protective efficacy against henipavirus disease. Studies have shown that nonhuman primates are the most accurate model of human henipavirus disease and would be an important component of any application for licensure of a vaccine or antiviral drug under the US FDA Animal Rule. Nonhuman primate model selection and dosing are discussed regarding vaccine and therapeutic studies against henipaviruses.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages159-173
Number of pages15
Volume2682
DOIs
StatePublished - Aug 24 2023

Publication series

NameMethods in Molecular Biology
Volume2682
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • African green monkey
  • Henipavirus
  • Treatment
  • Vaccination

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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