Nonhuman primate models of ebola virus disease

Richard S. Bennett, Louis M. Huzella, Peter B. Jahrling, Laura Bollinger, Gene G. Olinger, Lisa E. Hensley

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Scopus citations

Abstract

Ebola virus disease (EVD) in humans is associated with four ebolaviruses: Ebola virus (EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV), and Taï Forest virus. To date, no documented cases of human disease have been associated with Reston virus. Here, we describe the nonhuman primate (NHP) models that currently serve as gold standards for testing ebolavirus vaccines and therapeutic agents and elucidating underlying mechanisms of pathogenesis. Although multiple models have been explored over the past 50 years, the predominance of published work has been performed in macaque models. This chapter will focus on the most commonly used models.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages171-193
Number of pages23
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume411
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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