Abstract
Noninfectious uveitis encompasses a diverse group of ocular inflammatory disorders that share an underlying immune etiology and may be associated with systemic disease or confined primarily to the eye. Uveitis is commonly classified by anatomical location of inflammation into anterior, intermediate, posterior, and panuveitis. The treatment of noninfectious uveitis consists of corticosteroids, immunosuppressive agents, and surgically placed steroid implants. We review the epidemiology, immunopathology, and clinical features of several noninfectious immune-mediated uveitides, including HLA-B27 acute anterior uveitis, juvenile idiopathic arthritis, intermediate uveitis, sarcoidosis, Behcet's disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, and white dot syndromes. We also discuss the stepwise approach to medical treatment of immune-mediated uveitis as well as the characteristics, safety, and efficacy of immunosuppressive agents used to treat ocular inflammatory disease.
| Original language | English (US) |
|---|---|
| Article number | 409 |
| Journal | Current Allergy and Asthma Reports |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2014 |
Keywords
- Corticosteroid
- HLA-B27
- Immunomodulatory therapy
- Iritis
- Ocular inflammation
- Panuveitis
- Pars planitis
- Posterior uveitis
- Steroid implant
- Systemic disease
- Uveitis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pulmonary and Respiratory Medicine