Noninfectious immune-mediated uveitis and ocular inflammation

Jennifer Pan, Manuj Kapur, Rex McCallum

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Noninfectious uveitis encompasses a diverse group of ocular inflammatory disorders that share an underlying immune etiology and may be associated with systemic disease or confined primarily to the eye. Uveitis is commonly classified by anatomical location of inflammation into anterior, intermediate, posterior, and panuveitis. The treatment of noninfectious uveitis consists of corticosteroids, immunosuppressive agents, and surgically placed steroid implants. We review the epidemiology, immunopathology, and clinical features of several noninfectious immune-mediated uveitides, including HLA-B27 acute anterior uveitis, juvenile idiopathic arthritis, intermediate uveitis, sarcoidosis, Behcet's disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, and white dot syndromes. We also discuss the stepwise approach to medical treatment of immune-mediated uveitis as well as the characteristics, safety, and efficacy of immunosuppressive agents used to treat ocular inflammatory disease.

Original languageEnglish (US)
Article number409
JournalCurrent Allergy and Asthma Reports
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Corticosteroid
  • HLA-B27
  • Immunomodulatory therapy
  • Iritis
  • Ocular inflammation
  • Panuveitis
  • Pars planitis
  • Posterior uveitis
  • Steroid implant
  • Systemic disease
  • Uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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