Abstract
OBJECTIVE - To study the feasibility of noninvasive blood glucose monitoring using optical coherence tomography (OCT) technique in healthy volunteers. RESEARCH DESIGN AND METHODS - An OCT system with the wavelength of 1,300 nm was used in 15 healthy subjects in 18 clinical experiments. Standard oral glucose tolerance tests were performed to induce changes in blood glucose concentration. Blood samples were taken from the right arm vein every 5 or 15 min. OCT images were taken every 10-20 s from the left forearm over a total period of 3 h. The slope of the signals was calculated at the depth of 200-600 μm from the skin surface. RESULTS - A total of 426 blood samples and 8,437 OCT images and signals were collected and analyzed in these experiments. There was a good correlation between changes in the slope of noninvasively measured OCT signals and blood glucose concentrations throughout the duration of the experiments. The slope of OCT signals changed significantly (up to 2.8% per 10 mg/dl) with variation of plasma glucose values. The good correlation obtained between the OCT signal slope and blood glucose concentration is due to the coherent detection of backscattered photons, which allows measurements of OCT signal from a specific tissue layer without unwanted signal from other tissue layers. CONCLUSIONS - This pilot study demonstrated the capability of the OCT technique to monitor blood glucose concentration noninvasively in human subjects. Further studies with a larger number of subjects including diabetic subjects are planned to validate these preliminary results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2263-2267 |
| Number of pages | 5 |
| Journal | Diabetes Care |
| Volume | 25 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2002 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Noninvasive blood glucose monitoring with optical coherence tomography : A pilot study in human subjects. / Larin, Kirill V.; Eledrisi, Mohsen S.; Motamedi, Massoud; Esenaliev, Rinat.
In: Diabetes Care, Vol. 25, No. 12, 12.2002, p. 2263-2267.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noninvasive blood glucose monitoring with optical coherence tomography
T2 - A pilot study in human subjects
AU - Larin, Kirill V.
AU - Eledrisi, Mohsen S.
AU - Motamedi, Massoud
AU - Esenaliev, Rinat
PY - 2002/12
Y1 - 2002/12
N2 - OBJECTIVE - To study the feasibility of noninvasive blood glucose monitoring using optical coherence tomography (OCT) technique in healthy volunteers. RESEARCH DESIGN AND METHODS - An OCT system with the wavelength of 1,300 nm was used in 15 healthy subjects in 18 clinical experiments. Standard oral glucose tolerance tests were performed to induce changes in blood glucose concentration. Blood samples were taken from the right arm vein every 5 or 15 min. OCT images were taken every 10-20 s from the left forearm over a total period of 3 h. The slope of the signals was calculated at the depth of 200-600 μm from the skin surface. RESULTS - A total of 426 blood samples and 8,437 OCT images and signals were collected and analyzed in these experiments. There was a good correlation between changes in the slope of noninvasively measured OCT signals and blood glucose concentrations throughout the duration of the experiments. The slope of OCT signals changed significantly (up to 2.8% per 10 mg/dl) with variation of plasma glucose values. The good correlation obtained between the OCT signal slope and blood glucose concentration is due to the coherent detection of backscattered photons, which allows measurements of OCT signal from a specific tissue layer without unwanted signal from other tissue layers. CONCLUSIONS - This pilot study demonstrated the capability of the OCT technique to monitor blood glucose concentration noninvasively in human subjects. Further studies with a larger number of subjects including diabetic subjects are planned to validate these preliminary results.
AB - OBJECTIVE - To study the feasibility of noninvasive blood glucose monitoring using optical coherence tomography (OCT) technique in healthy volunteers. RESEARCH DESIGN AND METHODS - An OCT system with the wavelength of 1,300 nm was used in 15 healthy subjects in 18 clinical experiments. Standard oral glucose tolerance tests were performed to induce changes in blood glucose concentration. Blood samples were taken from the right arm vein every 5 or 15 min. OCT images were taken every 10-20 s from the left forearm over a total period of 3 h. The slope of the signals was calculated at the depth of 200-600 μm from the skin surface. RESULTS - A total of 426 blood samples and 8,437 OCT images and signals were collected and analyzed in these experiments. There was a good correlation between changes in the slope of noninvasively measured OCT signals and blood glucose concentrations throughout the duration of the experiments. The slope of OCT signals changed significantly (up to 2.8% per 10 mg/dl) with variation of plasma glucose values. The good correlation obtained between the OCT signal slope and blood glucose concentration is due to the coherent detection of backscattered photons, which allows measurements of OCT signal from a specific tissue layer without unwanted signal from other tissue layers. CONCLUSIONS - This pilot study demonstrated the capability of the OCT technique to monitor blood glucose concentration noninvasively in human subjects. Further studies with a larger number of subjects including diabetic subjects are planned to validate these preliminary results.
UR - http://www.scopus.com/inward/record.url?scp=0038628894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038628894&partnerID=8YFLogxK
U2 - 10.2337/diacare.25.12.2263
DO - 10.2337/diacare.25.12.2263
M3 - Article
C2 - 12453971
AN - SCOPUS:0038628894
VL - 25
SP - 2263
EP - 2267
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 12
ER -