TY - JOUR
T1 - Noninvasive intestinal amebiasis
T2 - Entamoeba histolytica colonization without invasion
AU - Nair, Gayatri V.
AU - Variyam, Easwaran P.
PY - 2014/10
Y1 - 2014/10
N2 - PURPOSE OF REVIEW: Entamoeba histolytica infection remains a major cause of morbidity and mortality worldwide. Although research with the organism began in the late nineteenth century, our understanding of the natural history of the infection remains incomplete and is heavily based on expert opinion. Most persons infected with E. histolytica are carriers with the organism colonizing the large intestine. Host defense mechanisms that prevent invasive diseases are poorly understood. A timely review could lead to renewed interest. RECENT FINDINGS: We herein review 2012 and 2013 publications related to the epidemiology, diagnosis, management and potential mechanisms that enable noninvasive E. histolytica colonization without invasion. SUMMARY: There are several publications that advance our knowledge in the first three categories listed above, but studies of mechanisms for noninvasive E. histolytica colonization are glaringly few.
AB - PURPOSE OF REVIEW: Entamoeba histolytica infection remains a major cause of morbidity and mortality worldwide. Although research with the organism began in the late nineteenth century, our understanding of the natural history of the infection remains incomplete and is heavily based on expert opinion. Most persons infected with E. histolytica are carriers with the organism colonizing the large intestine. Host defense mechanisms that prevent invasive diseases are poorly understood. A timely review could lead to renewed interest. RECENT FINDINGS: We herein review 2012 and 2013 publications related to the epidemiology, diagnosis, management and potential mechanisms that enable noninvasive E. histolytica colonization without invasion. SUMMARY: There are several publications that advance our knowledge in the first three categories listed above, but studies of mechanisms for noninvasive E. histolytica colonization are glaringly few.
KW - Entamoeba histolytica infection
KW - amebiasis
KW - intestinal protozoa
UR - http://www.scopus.com/inward/record.url?scp=84906937860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906937860&partnerID=8YFLogxK
U2 - 10.1097/QCO.0000000000000095
DO - 10.1097/QCO.0000000000000095
M3 - Review article
C2 - 25101557
AN - SCOPUS:84906937860
SN - 0951-7375
VL - 27
SP - 465
EP - 469
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
IS - 5
ER -