Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system

Stephen Herrmann, Irene Y. Petrov, Yuriy Petrov, Rafael Fonseca, Carol Richardson, Ekaterina Shanina, Donald Prough, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Noninvasive measurement of cerebral venous oxygenation in neonates could provide critical information for clinicians such as cerebral hypoxia without the risks involved with invasive catheterization. Evaluation of cerebral hypoxia is important in many clinical settings such as hypoxic-ischemic encephalopathy, perfusion monitoring in cardiovascular surgery or in traumatic brain injury. By probing the superior sagittal sinus (SSS), a large central cerebral vein, we can obtain stable signals with our recently developed multi-wavelength, fiber-coupled laser diode optoacoustic system for measurement of SSS blood oxygenation. The neonatal SSS oxygenation was measured in the reflection mode through open anterior and posterior fontanelles without obscuration by the overlying calvarium. In the transmission mode it was measured through the skull in the occipital area. Our device is lightweight, easily maneuverable, and user friendly for physicians. We monitored the SSS oxygenation in neonates admitted to the Neonatal Intensive Care Unit (NICU) of UTMB with varying gestation, birth weight and clinical histories to identify normal range and difference between neonates with and without risk factors for cerebral hypoxia.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2018
PublisherSPIE
Volume10494
ISBN (Electronic)9781510614734
DOIs
StatePublished - Jan 1 2018
EventPhotons Plus Ultrasound: Imaging and Sensing 2018 - San Francisco, United States
Duration: Jan 28 2018Feb 1 2018

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2018
CountryUnited States
CitySan Francisco
Period1/28/182/1/18

Fingerprint

Superior Sagittal Sinus
sinuses
Optical fiber coupling
Semiconductor Lasers
Oxygenation
Photoacoustic effect
oxygenation
Brain Hypoxia
Semiconductor lasers
hypoxia
Cranial Fontanelles
semiconductor lasers
Newborn Infant
Wavelength
fibers
Skull
wavelengths
Cardiovascular surgery
catheterization
brain damage

Keywords

  • cerebral ischemia
  • cerebral oxygenation
  • imaging
  • neonatal
  • noninvasive monitoring
  • optoacoustic

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Herrmann, S., Petrov, I. Y., Petrov, Y., Fonseca, R., Richardson, C., Shanina, E., ... Esenaliev, R. (2018). Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system. In Photons Plus Ultrasound: Imaging and Sensing 2018 (Vol. 10494). [1049409] SPIE. https://doi.org/10.1117/12.2294057

Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system. / Herrmann, Stephen; Petrov, Irene Y.; Petrov, Yuriy; Fonseca, Rafael; Richardson, Carol; Shanina, Ekaterina; Prough, Donald; Esenaliev, Rinat.

Photons Plus Ultrasound: Imaging and Sensing 2018. Vol. 10494 SPIE, 2018. 1049409.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Herrmann, S, Petrov, IY, Petrov, Y, Fonseca, R, Richardson, C, Shanina, E, Prough, D & Esenaliev, R 2018, Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system. in Photons Plus Ultrasound: Imaging and Sensing 2018. vol. 10494, 1049409, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2018, San Francisco, United States, 1/28/18. https://doi.org/10.1117/12.2294057
Herrmann S, Petrov IY, Petrov Y, Fonseca R, Richardson C, Shanina E et al. Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system. In Photons Plus Ultrasound: Imaging and Sensing 2018. Vol. 10494. SPIE. 2018. 1049409 https://doi.org/10.1117/12.2294057
Herrmann, Stephen ; Petrov, Irene Y. ; Petrov, Yuriy ; Fonseca, Rafael ; Richardson, Carol ; Shanina, Ekaterina ; Prough, Donald ; Esenaliev, Rinat. / Noninvasive measurement of cerebral venous oxygenation in neonates with a multi-wavelength, fiber-coupled laser diode optoacoustic system. Photons Plus Ultrasound: Imaging and Sensing 2018. Vol. 10494 SPIE, 2018.
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