Noninvasive monitoring of glucose concentration with optical coherence tomography

Rinat Esenaliev, Krill V. Larin, Irina V. Larina, Massoud Motamedi

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

We have proposed a tested in tissue phantoms and in vivo a novel sensor based on optical coherence tomography (OCT) for noninvasive and continuous monitoring of blood glucose concentration. OCT images were obtained from pig and rabbit skin before and after glucose administration. Slopes of OCT signals decreased substantially (∼40% in tissues in vivo) and linearly with the increase of blood glucose concentration from 4 to 30 mM, typical for normal and diabetic subjects. Phantom studies demonstrated 1% accuracy of scattering-coefficient measurement. Our theoretical and experimental studies suggest that glucose concentration can potentially be measured noninvasively with high sensitivity and accuracy with OCT systems.

Original languageEnglish (US)
Pages (from-to)992-994
Number of pages3
JournalOptics Letters
Volume26
Issue number13
StatePublished - Jul 1 2001

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glucose
tomography
blood
swine
rabbits
scattering coefficients
slopes
sensitivity
sensors

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Noninvasive monitoring of glucose concentration with optical coherence tomography. / Esenaliev, Rinat; Larin, Krill V.; Larina, Irina V.; Motamedi, Massoud.

In: Optics Letters, Vol. 26, No. 13, 01.07.2001, p. 992-994.

Research output: Contribution to journalArticle

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