Noninvasive, optoacoustic detection and characterization of intra- and extracranial hematomas and cerebral hypoxia

Andrey Petrov, Donald Prough, Yuriy Petrov, Irene Y. Petrov, Claudia S. Robertson, Vasantha Asokan, Adaeze Agbor, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Early diagnosis of intracranial hematomas is necessary to improve outcome in patients with traumatic brain injury (TBI). CT and MRI can diagnose intracranial hematomas, but cannot be used until the patient arrives at a major healthcare facility, resulting in delayed diagnosis. Near infrared spectroscopy may suggest the presence of unilateral intracranial hematomas, but provides minimal information on hematoma type and location due to limitations associated with strong light scattering. We have used optoacoustics (which combines high endogenous optical contrast with the resolution of ultrasound) to diagnose hematomas and monitor cerebral oxygenation. We performed animal and clinical studies on detection and characterization of hematomas and on monitoring cerebral hypoxia by probing the superior sagittal sinus (SSS). Recently, we built a medical grade, multi-wavelength, OPO-based optoacoustic system tunable in the near infrared spectral range. We developed new patient interfaces for noninvasive, transcranial measurements in the transmission mode in the presence of dense hair and used it in patients with TBI. The optoacoustic system was capable of detecting and characterizing intra- and extracranial hematomas. SSS blood oxygenation was measured as well with the new interface. The obtained results indicate that the optoacoustic system in the transmission mode provides detection and characterization of hematomas in TBI patients, as well as cerebral venous blood oxygenation monitoring. The transmission mode approach can be used for optoacoustic brain imaging, tomography, and mapping in humans.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9323
ISBN (Print)9781628414134
DOIs
StatePublished - 2015
EventPhotons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States
Duration: Feb 8 2015Feb 10 2015

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2015
CountryUnited States
CitySan Francisco
Period2/8/152/10/15

Fingerprint

Brain Hypoxia
Photoacoustic effect
hypoxia
Hematoma
brain damage
Oxygenation
oxygenation
Brain
sinuses
blood
Superior Sagittal Sinus
Blood
Near infrared spectroscopy
Monitoring
hair
Light scattering
Magnetic resonance imaging
brain
Tomography
animals

Keywords

  • Cerebral blood saturation
  • Hematoma
  • Imaging
  • Noninvasive monitoring
  • Optoacoustics

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, A., Prough, D., Petrov, Y., Petrov, I. Y., Robertson, C. S., Asokan, V., ... Esenaliev, R. (2015). Noninvasive, optoacoustic detection and characterization of intra- and extracranial hematomas and cerebral hypoxia. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9323). [93233N] SPIE. https://doi.org/10.1117/12.2085080

Noninvasive, optoacoustic detection and characterization of intra- and extracranial hematomas and cerebral hypoxia. / Petrov, Andrey; Prough, Donald; Petrov, Yuriy; Petrov, Irene Y.; Robertson, Claudia S.; Asokan, Vasantha; Agbor, Adaeze; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9323 SPIE, 2015. 93233N.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, A, Prough, D, Petrov, Y, Petrov, IY, Robertson, CS, Asokan, V, Agbor, A & Esenaliev, R 2015, Noninvasive, optoacoustic detection and characterization of intra- and extracranial hematomas and cerebral hypoxia. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9323, 93233N, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2015, San Francisco, United States, 2/8/15. https://doi.org/10.1117/12.2085080
Petrov A, Prough D, Petrov Y, Petrov IY, Robertson CS, Asokan V et al. Noninvasive, optoacoustic detection and characterization of intra- and extracranial hematomas and cerebral hypoxia. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9323. SPIE. 2015. 93233N https://doi.org/10.1117/12.2085080
Petrov, Andrey ; Prough, Donald ; Petrov, Yuriy ; Petrov, Irene Y. ; Robertson, Claudia S. ; Asokan, Vasantha ; Agbor, Adaeze ; Esenaliev, Rinat. / Noninvasive, optoacoustic detection and characterization of intra- and extracranial hematomas and cerebral hypoxia. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9323 SPIE, 2015.
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