Noninvasive optoacoustic system for rapid diagnosis and management of circulatory shock

Irene Y. Petrov, Michael Kinsky, Yuriy Petrov, Andrey Petrov, S. N. Henkel, Roger Seeton, Rinat O. Esenaliev, Donald S. Prough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

Circulatory shock can lead to death or severe complications, if not promptly diagnosed and effectively treated. Typically, diagnosis and management of circulatory shock are guided by blood pressure and heart rate. However, these variables have poor specificity, sensitivity, and predictive value. Early goal-directed therapy in septic shock patients, using central venous catheterization (CVC), reduced mortality from 46.5% to 30%. However, CVC is invasive and complication-prone. We proposed to use an optoacoustic technique for noninvasive, rapid assessment of peripheral and central venous oxygenation. In this work we used a medical grade optoacoustic system for noninvasive, ultrasound image-guided measurement of central and peripheral venous oxygenation. Venous oxygenation during shock declines more rapidly in the periphery than centrally. Ultrasound imaging of the axillary [peripheral] and internal jugular vein [central] was performed using the Vivid e (GE Healthcare). We built an optoacoustic interface incorporating an optoacoustic transducer and a standard ultrasound imaging probe. Central and peripheral venous oxygenations were measured continuously in healthy volunteers. To simulate shock-induced changes in central and peripheral oxygenation, we induced peripheral vasoconstriction in the upper extremity by using a cooling blanket. Central and peripheral venous oxygenations were measured before (baseline) and after cooling and after rewarming. During the entire experiment, central venous oxygenation was relatively stable, while peripheral venous oxygenation decreased by 5-10% due to cooling and recovered after rewarming. The obtained data indicate that noninvasive, optoacoustic measurements of central and peripheral venous oxygenation may be used for diagnosis and management of circulatory shock with high sensitivity and specificity.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2013
DOIs
StatePublished - May 28 2013
EventPhotons Plus Ultrasound: Imaging and Sensing 2013 - San Francisco, CA, United States
Duration: Feb 3 2013Feb 5 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8581
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2013
CountryUnited States
CitySan Francisco, CA
Period2/3/132/5/13

Keywords

  • central venous oxygenation
  • circulatory shock
  • noninvasive monitoring
  • optoacoustics
  • ultrasound imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Petrov, I. Y., Kinsky, M., Petrov, Y., Petrov, A., Henkel, S. N., Seeton, R., Esenaliev, R. O., & Prough, D. S. (2013). Noninvasive optoacoustic system for rapid diagnosis and management of circulatory shock. In Photons Plus Ultrasound: Imaging and Sensing 2013 [85814Y] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8581). https://doi.org/10.1117/12.2010434