Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock

Rinat Esenaliev, Irene Y. Petrov, Yuriy Petrov, Michael Kinsky, Donald Prough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Circulatory shock is lethal, if not promptly diagnosed and effectively treated. Typically, circulatory shock resuscitation is guided by blood pressure, heart rate, and mental status, which have poor predictive value. In patients, in whom early goaldirected therapy was applied using central venous oxygenation measurement, a substantial reduction of mortality was reported (from 46.5% to 30%). However, central venous catheterization is invasive, time-consuming and often results in complications. We proposed to use the optoacoustic technique for noninvasive, rapid assessment of central venous oxygenation. In our previous works we demonstrated that the optoacoustic technique can provide measurement of blood oxygenation in veins and arteries due to high contrast and high resolution. In this work we developed a novel optoacoustic system for noninvasive, automatic, real-time, and continuous measurement of central venous oxygenation. We performed pilot clinical tests of the system in human subjects with different oxygenation in the internal jugular vein and subclavian vein. A novel optoacoustic interface incorporating highly-sensitive optoacoustic probes and standard ultrasound imaging probes were developed and built for the study. Ultrasound imaging systems Vivid i and hand-held Vscan (GE Healthcare) as well as Site-Rite 5 (C.R. Bard) were used in the study. We developed a special algorithm for oxygenation monitoring with minimal influence of overlying tissue. The data demonstrate that the system provides precise measurement of venous oxygenation continuously and in real time. Both current value of the venous oxygenation and trend (in absolute values and for specified time intervals) are displayed in the system. The data indicate that: 1) the optoacoustic system developed by our group is capable of noninvasive measurement of blood oxygenation in specific veins; 2) clinical ultrasound imaging systems can facilitate optoacoustic probing of specific blood vessels; 3) the optoacoustic system provides noninvasive monitoring during rapid changes in blood oxygenation.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8223
DOIs
StatePublished - 2012
EventPhotons Plus Ultrasound: Imaging and Sensing 2012 - San Francisco, CA, United States
Duration: Jan 22 2012Jan 24 2012

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2012
CountryUnited States
CitySan Francisco, CA
Period1/22/121/24/12

Fingerprint

Oxygenation
Photoacoustic effect
oxygenation
Photoacoustic Techniques
Shock
shock
Ultrasonography
Veins
veins
Central Venous Catheterization
Subclavian Vein
Jugular Veins
blood
Secondary Prevention
Information Systems
Resuscitation
Blood
Ultrasonics
Blood Vessels
Hand

Keywords

  • Central venous oxygenation
  • Circulatory shock
  • Noninvasive monitoring
  • Optoacoustics
  • Ultrasound imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Esenaliev, R., Petrov, I. Y., Petrov, Y., Kinsky, M., & Prough, D. (2012). Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8223). [82230F] https://doi.org/10.1117/12.914653

Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock. / Esenaliev, Rinat; Petrov, Irene Y.; Petrov, Yuriy; Kinsky, Michael; Prough, Donald.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8223 2012. 82230F.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Esenaliev, R, Petrov, IY, Petrov, Y, Kinsky, M & Prough, D 2012, Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8223, 82230F, Photons Plus Ultrasound: Imaging and Sensing 2012, San Francisco, CA, United States, 1/22/12. https://doi.org/10.1117/12.914653
Esenaliev R, Petrov IY, Petrov Y, Kinsky M, Prough D. Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8223. 2012. 82230F https://doi.org/10.1117/12.914653
Esenaliev, Rinat ; Petrov, Irene Y. ; Petrov, Yuriy ; Kinsky, Michael ; Prough, Donald. / Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8223 2012.
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