Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue

Beop Min Kim, Steven L. Jacques, Sohi Rastegar, Sharon Thomsen, Massoud Motamedi

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

A nonlinear finite-element program was developed to simulate the dynamic evolution of coagulation in tissue considering temperature and damage dependence of both the optical properties and blood perfusion rate. These dynamic parameters were derived based on the Arrhenius rate process formulation of thermal damage and kinetics of vasodilation. Using this nonlinear model, we found that the region of increased blood flow that formed at the periphery of the coagulation region significantly reduces the heat penetration. Moreover, increased scattering in the near-surface region prevents light penetration into the deeper region. Therefore, if the dynamic parameters are ignored, a relatively significant overestimation of the temperature rise occurs in a deeper area resulting in an overestimation in predicted depth of coagulation. Mathematical modeling techniques that simulate laser coagulation may not provide reliable information unless they take into account these dynamic parameters.

Original languageEnglish (US)
Pages (from-to)922-933
Number of pages12
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume2
Issue number4
DOIs
StatePublished - Dec 1996

Fingerprint

coagulation
Coagulation
blood
Blood
Optical properties
Tissue
Finite element method
optical properties
Lasers
lasers
vasodilation
penetration
damage
blood flow
Scattering
formulations
heat
Temperature
temperature dependence
Kinetics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue. / Kim, Beop Min; Jacques, Steven L.; Rastegar, Sohi; Thomsen, Sharon; Motamedi, Massoud.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 2, No. 4, 12.1996, p. 922-933.

Research output: Contribution to journalArticle

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