Nonlipidized juvenile xanthogranuloma: A histologic and immunohistochemical study

Cathy C. Newman, Sharon Raimer, Ramón L. Sánchez

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Among all patients with a pathologic diagnosis of juvenile xanthogranuloma (JXG) seen at our institution from 1983 to 1994, we identified five patients with an unusual histologic pattern that differed from the classic juvenile xanthogranuloma (CJXG) with foamy cells and Touton giant cells. Four of these five cases, which we termed nonlipidized juvenile xanthogranuloma (NJXG), were seen in infants. The histologic features include a monomorphic infiltrate with absent or few foam cells and Touton giant cells. There is little inflammation, and mitotic figures are easily found. Four cases exhibit a diffuse sheetlike pattern while one is trabecular. Immunoperoxidase staining was done. All lesions are consistently positive for factor XIIIa as opposed to only focally positive or negative in CJXG and negative in Langerhans cell histiocytosis (LCH). The S-190 was negative. NJXG represents an atypical histologic variant of JXG, which may suggest a malignant or aggressive tumor. The followup, however, indicates that these lesions behave in a fashion similar to those of CJXG. The differential diagnosis should be made with LCH, intradermal nevus, and reticulohistiocytosis. The immunoperoxidase findings help to differentiate NJXG from these entities.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalPediatric Dermatology
Volume14
Issue number2
StatePublished - Mar 1997

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Juvenile Xanthogranuloma
Langerhans Cell Histiocytosis
Giant Cells
Intradermal Nevus
Factor XIIIa
Foam Cells
Differential Diagnosis
Staining and Labeling
Inflammation

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health

Cite this

Newman, C. C., Raimer, S., & Sánchez, R. L. (1997). Nonlipidized juvenile xanthogranuloma: A histologic and immunohistochemical study. Pediatric Dermatology, 14(2), 98-102.

Nonlipidized juvenile xanthogranuloma : A histologic and immunohistochemical study. / Newman, Cathy C.; Raimer, Sharon; Sánchez, Ramón L.

In: Pediatric Dermatology, Vol. 14, No. 2, 03.1997, p. 98-102.

Research output: Contribution to journalArticle

Newman, CC, Raimer, S & Sánchez, RL 1997, 'Nonlipidized juvenile xanthogranuloma: A histologic and immunohistochemical study', Pediatric Dermatology, vol. 14, no. 2, pp. 98-102.
Newman, Cathy C. ; Raimer, Sharon ; Sánchez, Ramón L. / Nonlipidized juvenile xanthogranuloma : A histologic and immunohistochemical study. In: Pediatric Dermatology. 1997 ; Vol. 14, No. 2. pp. 98-102.
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