Abstract
The G-band locations of 3244 breakpoints induced by cis-platinum (II) diamminedichloride (PDD), 1460 breakpoints induced by cytosine arabinoside (ara-C), and 1257 breakpoints induced by triethylenemelamine (TEM) in human lymphocyte chromosomes were identified. The breakpoints induced by each of these chemicals demonstrated a significantly nonrandom distribution within the human karyotype. The overall pattern of the interarm distribution was dependent upon the chemical used, but certain chromosome arms exhibited similar responses to all 3 chemicals. Comparison of the frequencies of breakpoints within individual G-bands indicated that (1) certain bands were susceptible to damage induced by all 3 chemicals; (2) certain bands were resistant to damage by all 3 chemicals; (3) certain bands demonstrated variable susceptibility to induced damage dependent upon the chemical agent; and (4) other bands demonstrated near expected frequencies of damage (by length) to all 3 agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 201-209 |
| Number of pages | 9 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
Nonrandom distribution of chromosomal aberrations induced by three chemicals. / Meyne, Julianne; Lockhart, Lillian; Arrighi, F. E.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 63, No. 1, 1979, p. 201-209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonrandom distribution of chromosomal aberrations induced by three chemicals
AU - Meyne, Julianne
AU - Lockhart, Lillian
AU - Arrighi, F. E.
PY - 1979
Y1 - 1979
N2 - The G-band locations of 3244 breakpoints induced by cis-platinum (II) diamminedichloride (PDD), 1460 breakpoints induced by cytosine arabinoside (ara-C), and 1257 breakpoints induced by triethylenemelamine (TEM) in human lymphocyte chromosomes were identified. The breakpoints induced by each of these chemicals demonstrated a significantly nonrandom distribution within the human karyotype. The overall pattern of the interarm distribution was dependent upon the chemical used, but certain chromosome arms exhibited similar responses to all 3 chemicals. Comparison of the frequencies of breakpoints within individual G-bands indicated that (1) certain bands were susceptible to damage induced by all 3 chemicals; (2) certain bands were resistant to damage by all 3 chemicals; (3) certain bands demonstrated variable susceptibility to induced damage dependent upon the chemical agent; and (4) other bands demonstrated near expected frequencies of damage (by length) to all 3 agents.
AB - The G-band locations of 3244 breakpoints induced by cis-platinum (II) diamminedichloride (PDD), 1460 breakpoints induced by cytosine arabinoside (ara-C), and 1257 breakpoints induced by triethylenemelamine (TEM) in human lymphocyte chromosomes were identified. The breakpoints induced by each of these chemicals demonstrated a significantly nonrandom distribution within the human karyotype. The overall pattern of the interarm distribution was dependent upon the chemical used, but certain chromosome arms exhibited similar responses to all 3 chemicals. Comparison of the frequencies of breakpoints within individual G-bands indicated that (1) certain bands were susceptible to damage induced by all 3 chemicals; (2) certain bands were resistant to damage by all 3 chemicals; (3) certain bands demonstrated variable susceptibility to induced damage dependent upon the chemical agent; and (4) other bands demonstrated near expected frequencies of damage (by length) to all 3 agents.
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U2 - 10.1016/0027-5107(79)90116-7
DO - 10.1016/0027-5107(79)90116-7
M3 - Article
VL - 63
SP - 201
EP - 209
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 1
ER -