@article{d42335ce89934ef8bb24aae757fa0141,
title = "Nonrandom distribution of chromosomal aberrations induced by three chemicals",
abstract = "The G-band locations of 3244 breakpoints induced by cis-platinum (II) diamminedichloride (PDD), 1460 breakpoints induced by cytosine arabinoside (ara-C), and 1257 breakpoints induced by triethylenemelamine (TEM) in human lymphocyte chromosomes were identified. The breakpoints induced by each of these chemicals demonstrated a significantly nonrandom distribution within the human karyotype. The overall pattern of the interarm distribution was dependent upon the chemical used, but certain chromosome arms exhibited similar responses to all 3 chemicals. Comparison of the frequencies of breakpoints within individual G-bands indicated that (1) certain bands were susceptible to damage induced by all 3 chemicals; (2) certain bands were resistant to damage by all 3 chemicals; (3) certain bands demonstrated variable susceptibility to induced damage dependent upon the chemical agent; and (4) other bands demonstrated near expected frequencies of damage (by length) to all 3 agents.",
author = "Julianne Meyne and Lillian Lockhart and Arrighi, {F. E.}",
year = "1979",
doi = "10.1016/0027-5107(79)90116-7",
language = "English (US)",
volume = "63",
pages = "201--209",
journal = "Mutation Research",
issn = "0027-5107",
publisher = "Elsevier",
number = "1",
}