Normal values of urinary albumin and total protein excretion during pregnancy

Kenneth Higby, Cheryl R. Suiter, John Y. Phelps, Theresa Siler-Khodr, Oded Langer

Research output: Contribution to journalArticle

124 Scopus citations

Abstract

Objective: Our purpose was to determine the normal 24-hour excretion values of urinary albumin and total protein in healthy pregnant women. Study Design: We evaluated 270 healthy pregnant women ≤ 35 years old without a history of diabetes, hypertension, pyelonephritis, preeclampsia, or renal or connective tissue disease. Adequacy of 24-hour collection was determined by creatinine excretion. Results: The mean protein excretion in 24 hours was 116.9 mg, upper 95% confidence limit 259.4 mg. The mean albumin excretion in 24 hours was 11.8 mg, upper 95% confidence limit 28.7 mg. Both protein and albumin excretion increased after 20 weeks of gestation. No patient had evidence of microalbuminuria, defined as urinary albumin excretion 〉30 mg/L. Conclusion: These data support 260 mg per 24 hours of urinary protein and 29 mg per 24 hours of albumin as the upper limit of normal in pregnancy. Albumin accounts for a small fraction of total urinary protein excretion.

Original languageEnglish (US)
Pages (from-to)984-989
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume171
Issue number4
DOIs
StatePublished - Jan 1 1994

Keywords

  • Urinary protein excretion
  • pregnancy
  • urinary albumin excretion

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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