TY - JOUR
T1 - Normal values of urinary albumin and total protein excretion during pregnancy
AU - Higby, Kenneth
AU - Suiter, Cheryl R.
AU - Phelps, John Y.
AU - Siler-Khodr, Theresa
AU - Langer, Oded
PY - 1994
Y1 - 1994
N2 - Objective: Our purpose was to determine the normal 24-hour excretion values of urinary albumin and total protein in healthy pregnant women. Study Design: We evaluated 270 healthy pregnant women ≤ 35 years old without a history of diabetes, hypertension, pyelonephritis, preeclampsia, or renal or connective tissue disease. Adequacy of 24-hour collection was determined by creatinine excretion. Results: The mean protein excretion in 24 hours was 116.9 mg, upper 95% confidence limit 259.4 mg. The mean albumin excretion in 24 hours was 11.8 mg, upper 95% confidence limit 28.7 mg. Both protein and albumin excretion increased after 20 weeks of gestation. No patient had evidence of microalbuminuria, defined as urinary albumin excretion 〉30 mg/L. Conclusion: These data support 260 mg per 24 hours of urinary protein and 29 mg per 24 hours of albumin as the upper limit of normal in pregnancy. Albumin accounts for a small fraction of total urinary protein excretion.
AB - Objective: Our purpose was to determine the normal 24-hour excretion values of urinary albumin and total protein in healthy pregnant women. Study Design: We evaluated 270 healthy pregnant women ≤ 35 years old without a history of diabetes, hypertension, pyelonephritis, preeclampsia, or renal or connective tissue disease. Adequacy of 24-hour collection was determined by creatinine excretion. Results: The mean protein excretion in 24 hours was 116.9 mg, upper 95% confidence limit 259.4 mg. The mean albumin excretion in 24 hours was 11.8 mg, upper 95% confidence limit 28.7 mg. Both protein and albumin excretion increased after 20 weeks of gestation. No patient had evidence of microalbuminuria, defined as urinary albumin excretion 〉30 mg/L. Conclusion: These data support 260 mg per 24 hours of urinary protein and 29 mg per 24 hours of albumin as the upper limit of normal in pregnancy. Albumin accounts for a small fraction of total urinary protein excretion.
KW - Urinary protein excretion
KW - pregnancy
KW - urinary albumin excretion
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U2 - 10.1016/S0002-9378(13)90019-3
DO - 10.1016/S0002-9378(13)90019-3
M3 - Article
C2 - 7943114
AN - SCOPUS:0028077120
SN - 0002-9378
VL - 171
SP - 984
EP - 989
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 4
ER -