Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy

Martin Montes, Cesar Sanchez, Dorothy E. Lewis, Edward A. Graviss, Carlos Seas, Eduardo Gotuzzo, A. Clinton White

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.

Original languageEnglish (US)
Pages (from-to)496-499
Number of pages4
JournalJournal of Infectious Diseases
Volume203
Issue number4
DOIs
StatePublished - Feb 15 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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