Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy

Martin Montes, Cesar Sanchez, Dorothy E. Lewis, Edward A. Graviss, Carlos Seas, Eduardo Gotuzzo, A. Clinton White

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.

Original languageEnglish (US)
Pages (from-to)496-499
Number of pages4
JournalJournal of Infectious Diseases
Volume203
Issue number4
DOIs
StatePublished - Feb 15 2011

Fingerprint

Regulatory T-Lymphocytes
T-Lymphocytes
Virus Diseases
Reference Values
Cell Count
HIV
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy. / Montes, Martin; Sanchez, Cesar; Lewis, Dorothy E.; Graviss, Edward A.; Seas, Carlos; Gotuzzo, Eduardo; White, A. Clinton.

In: Journal of Infectious Diseases, Vol. 203, No. 4, 15.02.2011, p. 496-499.

Research output: Contribution to journalArticle

Montes, Martin ; Sanchez, Cesar ; Lewis, Dorothy E. ; Graviss, Edward A. ; Seas, Carlos ; Gotuzzo, Eduardo ; White, A. Clinton. / Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy. In: Journal of Infectious Diseases. 2011 ; Vol. 203, No. 4. pp. 496-499.
@article{5fd4dd30e3994f90a538d28223b71475,
title = "Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy",
abstract = "Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13{\%} at baseline to 5.1{\%} at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.",
author = "Martin Montes and Cesar Sanchez and Lewis, {Dorothy E.} and Graviss, {Edward A.} and Carlos Seas and Eduardo Gotuzzo and White, {A. Clinton}",
year = "2011",
month = "2",
day = "15",
doi = "10.1093/infdis/jiq073",
language = "English (US)",
volume = "203",
pages = "496--499",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy

AU - Montes, Martin

AU - Sanchez, Cesar

AU - Lewis, Dorothy E.

AU - Graviss, Edward A.

AU - Seas, Carlos

AU - Gotuzzo, Eduardo

AU - White, A. Clinton

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.

AB - Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.

UR - http://www.scopus.com/inward/record.url?scp=79751470192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79751470192&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiq073

DO - 10.1093/infdis/jiq073

M3 - Article

C2 - 21177309

AN - SCOPUS:79751470192

VL - 203

SP - 496

EP - 499

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -