Nosocomial sinusitis in patients in the medical intensive care unit: A prospective epidemiological study

David L. George, Pamela S. Falk, G. Umberto Meduri, Kenneth V. Leeper, Richard G. Wunderink, Elaine L. Steere, F. Kent Nunnally, Neal Beckford, C. Glen Mayhall

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

A prospective observational cohort study of nosocomial sinusitis was carried out in two medical intensive care units. Sinusitis was diagnosed by computed tomographic scanning and the culture of sinus fluid obtained by puncture of a maxillary sinus. Clinical and epidemiological data were collected at the time of admission to the unit and daily thereafter. Specimens from the nares, oropharynx, trachea, and stomach were cultured on admission and daily thereafter. The cumulative incidence of nosocomial sinusitis was 7.7%, and the incidence rates were 12 cases per 1,000 patient- days and 19.8 cases per 1,000 nasoenteric tube-days. Risk factors for nosocomial sinusitis, as determined by multiple logistic regression analysis, included nasal colonization with enteric gram-negative bacilli (odds ratio [OR], 6.4; 95% confidence interval [95% CI], 2.2-18.8; P = .007), feeding via nasoenteric tube (OR, 14.1; 95% CI, 1.7-117.6; P = .015), sedation (OR, 15.9; 95% CI, 1.9133.5; P = .011), and a Glasgow coma score of ≤7 (OR, 9.1; 95% CI, 3.0-27.3; P = .0001).

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalClinical Infectious Diseases
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    George, D. L., Falk, P. S., Meduri, G. U., Leeper, K. V., Wunderink, R. G., Steere, E. L., Nunnally, F. K., Beckford, N., & Mayhall, C. G. (1998). Nosocomial sinusitis in patients in the medical intensive care unit: A prospective epidemiological study. Clinical Infectious Diseases, 27(3), 463-470. https://doi.org/10.1086/514711