Novel anticancer compounds induce apoptosis in melanoma cells

Uppoor G. Bhat, Patricia A. Zipfel, Douglas Tyler, Andrei L. Gartel

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We previously described the identification of a nucleoside analog transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H- Pyrrolo[2,3-d]-pyrimidine-5-carboxamide) and FoxM1 inhibitor, thiazole antibiotic Siomycin A that were able to induce apoptosis in cancer cell lines of different origin. Here, we report the characterization of these drugs on a panel of melanoma cell lines. We found that in contrast to the common anti-melanoma drug dacarbazine (DTIC), ARC and thiazole antibiotics, Siomycin A and thiostrepton, efficiently inhibited growth and induced cell death in melanoma cell lines in low concentrations. Overexpression of the antiapoptotic protein Mcl-1 protected melanoma cells from apoptosis induced by these compounds. Furthermore, we found that ARC and Siomycin A synergistically induce apoptosis in DM833 melanoma cell line suggesting that they may antagonize different anti-apoptotic pathways in melanoma cells. In general, these drugs may represent important candidates for anti-cancer drug development against melanoma.

Original languageEnglish (US)
Pages (from-to)1851-1855
Number of pages5
JournalCell Cycle
Volume7
Issue number12
StatePublished - Jun 15 2008
Externally publishedYes

Fingerprint

Melanoma
Cells
Apoptosis
Thiazoles
Dacarbazine
4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide
AIDS-Related Complex
Pharmaceutical Preparations
Thiostrepton
Cell Line
Anti-Bacterial Agents
Cell death
Nucleosides
Neoplasms
Cell Death
siomycin A
Proteins
Growth

Keywords

  • Apoptosis
  • ARC
  • FoxM1
  • Mcl-1
  • Melanoma
  • Thiazole antibiotics

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

Bhat, U. G., Zipfel, P. A., Tyler, D., & Gartel, A. L. (2008). Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle, 7(12), 1851-1855.

Novel anticancer compounds induce apoptosis in melanoma cells. / Bhat, Uppoor G.; Zipfel, Patricia A.; Tyler, Douglas; Gartel, Andrei L.

In: Cell Cycle, Vol. 7, No. 12, 15.06.2008, p. 1851-1855.

Research output: Contribution to journalArticle

Bhat, UG, Zipfel, PA, Tyler, D & Gartel, AL 2008, 'Novel anticancer compounds induce apoptosis in melanoma cells', Cell Cycle, vol. 7, no. 12, pp. 1851-1855.
Bhat UG, Zipfel PA, Tyler D, Gartel AL. Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle. 2008 Jun 15;7(12):1851-1855.
Bhat, Uppoor G. ; Zipfel, Patricia A. ; Tyler, Douglas ; Gartel, Andrei L. / Novel anticancer compounds induce apoptosis in melanoma cells. In: Cell Cycle. 2008 ; Vol. 7, No. 12. pp. 1851-1855.
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