Novel anticancer compounds induce apoptosis in melanoma cells

Uppoor G. Bhat, Patricia A. Zipfel, Douglas S. Tyler, Andrei L. Gartel

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

We previously described the identification of a nucleoside analog transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H- Pyrrolo[2,3-d]-pyrimidine-5-carboxamide) and FoxM1 inhibitor, thiazole antibiotic Siomycin A that were able to induce apoptosis in cancer cell lines of different origin. Here, we report the characterization of these drugs on a panel of melanoma cell lines. We found that in contrast to the common anti-melanoma drug dacarbazine (DTIC), ARC and thiazole antibiotics, Siomycin A and thiostrepton, efficiently inhibited growth and induced cell death in melanoma cell lines in low concentrations. Overexpression of the antiapoptotic protein Mcl-1 protected melanoma cells from apoptosis induced by these compounds. Furthermore, we found that ARC and Siomycin A synergistically induce apoptosis in DM833 melanoma cell line suggesting that they may antagonize different anti-apoptotic pathways in melanoma cells. In general, these drugs may represent important candidates for anti-cancer drug development against melanoma.

Original languageEnglish (US)
Pages (from-to)1851-1855
Number of pages5
JournalCell Cycle
Volume7
Issue number12
DOIs
StatePublished - Jun 15 2008
Externally publishedYes

Keywords

  • ARC
  • Apoptosis
  • FoxM1
  • Mcl-1
  • Melanoma
  • Thiazole antibiotics

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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