Novel approaches for mechanistic understanding and predicting preeclampsia

Satyan Kalkunte, Zhongbin Lai, Wendy E. Norris, Linda A. Pietras, Neetu Tewari, Roland Boij, Stefan Neubeck, Udo R. Markert, Surendra Sharma

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Despite intense investigation, preeclampsia (PE) remains largely enigmatic. Relatively late onset of diagnostic signs and heterogeneous nature of the disease further contribute to poor understanding of its etiology and clinical management. There exist no concrete animal models that can provide mechanistic underpinnings for evaluating targeted therapeutic intervention. Poor cross-sectional findings with potential biochemical markers reported so far have proved counterintuitive and suggest a need for novel approaches to predict the early onset of disease. Because of the co-onset of local placental anomalies and systemic manifestation of symptoms, it is highly likely that serum from PE patients can provide a "blueprint" of causative factors. Proteomic and/or functional analysis of maternal serum are expected to predict the onset of disease ahead of manifestation of clinical symptoms. A serum-based predictive assay should overcome complexities resulting from the heterogeneous etiology of PE. This review attempts to address some of these issues and discuss the signature biochemical serum factors and propose new and better ways to predict PE.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalJournal of Reproductive Immunology
Issue number1-2
StatePublished - Jan 2009
Externally publishedYes


  • Biological assay
  • Preeclampsia
  • Pregnancy serum
  • Proteomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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