Novel Bartonella species in insectivorous bats, Northern China

Hui Ju Han, Hong Ling Wen, Li Zhao, Jian Wei Liu, Li Mei Luo, Chuan Min Zhou, Xiang Rong Qin, Ye Lei Zhu, Xue Xing Zheng, Xue Jie Yu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2% (27/107) bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.

Original languageEnglish (US)
Article numbere0167915
JournalPLoS One
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Bartonella
Biodiversity
Pathogens
Ecology
Ports and harbors
Chiroptera
Amplification
China
Genes
Rhinolophus
Myotis
Myotis ricketti
gene amplification
genetic variation
Gene Amplification
mixed infection
Coinfection

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Han, H. J., Wen, H. L., Zhao, L., Liu, J. W., Luo, L. M., Zhou, C. M., ... Yu, X. J. (2017). Novel Bartonella species in insectivorous bats, Northern China. PLoS One, 12(1), [e0167915]. https://doi.org/10.1371/journal.pone.0167915

Novel Bartonella species in insectivorous bats, Northern China. / Han, Hui Ju; Wen, Hong Ling; Zhao, Li; Liu, Jian Wei; Luo, Li Mei; Zhou, Chuan Min; Qin, Xiang Rong; Zhu, Ye Lei; Zheng, Xue Xing; Yu, Xue Jie.

In: PLoS One, Vol. 12, No. 1, e0167915, 01.01.2017.

Research output: Contribution to journalArticle

Han, HJ, Wen, HL, Zhao, L, Liu, JW, Luo, LM, Zhou, CM, Qin, XR, Zhu, YL, Zheng, XX & Yu, XJ 2017, 'Novel Bartonella species in insectivorous bats, Northern China', PLoS One, vol. 12, no. 1, e0167915. https://doi.org/10.1371/journal.pone.0167915
Han HJ, Wen HL, Zhao L, Liu JW, Luo LM, Zhou CM et al. Novel Bartonella species in insectivorous bats, Northern China. PLoS One. 2017 Jan 1;12(1). e0167915. https://doi.org/10.1371/journal.pone.0167915
Han, Hui Ju ; Wen, Hong Ling ; Zhao, Li ; Liu, Jian Wei ; Luo, Li Mei ; Zhou, Chuan Min ; Qin, Xiang Rong ; Zhu, Ye Lei ; Zheng, Xue Xing ; Yu, Xue Jie. / Novel Bartonella species in insectivorous bats, Northern China. In: PLoS One. 2017 ; Vol. 12, No. 1.
@article{35c4f6fc635d47a5aba08121322d4366,
title = "Novel Bartonella species in insectivorous bats, Northern China",
abstract = "Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2{\%} (27/107) bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.",
author = "Han, {Hui Ju} and Wen, {Hong Ling} and Li Zhao and Liu, {Jian Wei} and Luo, {Li Mei} and Zhou, {Chuan Min} and Qin, {Xiang Rong} and Zhu, {Ye Lei} and Zheng, {Xue Xing} and Yu, {Xue Jie}",
year = "2017",
month = "1",
day = "1",
doi = "10.1371/journal.pone.0167915",
language = "English (US)",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

TY - JOUR

T1 - Novel Bartonella species in insectivorous bats, Northern China

AU - Han, Hui Ju

AU - Wen, Hong Ling

AU - Zhao, Li

AU - Liu, Jian Wei

AU - Luo, Li Mei

AU - Zhou, Chuan Min

AU - Qin, Xiang Rong

AU - Zhu, Ye Lei

AU - Zheng, Xue Xing

AU - Yu, Xue Jie

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2% (27/107) bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.

AB - Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2% (27/107) bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.

UR - http://www.scopus.com/inward/record.url?scp=85009292276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009292276&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0167915

DO - 10.1371/journal.pone.0167915

M3 - Article

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

M1 - e0167915

ER -