Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs)

Synthesis and antitumor activities

Gang Liu, Shanshan Song, Xiaohua Liu, Ao Zhang, Zehong Miao, Chunyong Ding

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated.

Original languageEnglish (US)
Pages (from-to)98975-98984
Number of pages10
JournalRSC Advances
Volume6
Issue number101
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Cycloaddition
Tumors
Screening
dihydroartemisinin
Carbon
Cells
artemisinine

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) : Synthesis and antitumor activities. / Liu, Gang; Song, Shanshan; Liu, Xiaohua; Zhang, Ao; Miao, Zehong; Ding, Chunyong.

In: RSC Advances, Vol. 6, No. 101, 01.01.2016, p. 98975-98984.

Research output: Contribution to journalArticle

Liu, Gang ; Song, Shanshan ; Liu, Xiaohua ; Zhang, Ao ; Miao, Zehong ; Ding, Chunyong. / Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) : Synthesis and antitumor activities. In: RSC Advances. 2016 ; Vol. 6, No. 101. pp. 98975-98984.
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