Novel finding of optic nerve central T2 hypointensity utilizing 3 tesla MR imaging

Roy Riascos, John C. Heymann, Reza Hakimelahi, Khader Hasan, Ashot Sargsyan, Yael R. Barr, James Tom, Noam Alperin, Larry A. Kramer

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations


    We sought to report a central T2 hypointensity within the optic nerve on 3 T MRI studies obtained as part of the NASA Flight Medicine Visual Impairment Intracranial Pressure Protocol that had not been described previously. Twenty-one astronauts, who had undergone MRI of both orbits with direct coronal T2 sequences between 2010 and 2012, were retrospectively included. Two of the astronauts did not have previous exposure to microgravity at the time of their scans. A central T2 hypointensity was observed in 100% of both right and left eyes. It was completely visualized throughout the nerve course in 15 right eyes (71.4%) and in 19 left eyes (90.5%).We describe a new finding seen in all study participants: a central T2 hypointensity in the epicenter of the optic nerve. We speculate that this T2 hypointensity may represent flow voids caused by the central retinal vessels.

    Original languageEnglish (US)
    Pages (from-to)133-136
    Number of pages4
    JournalNeuroradiology Journal
    Issue number2
    StatePublished - Apr 2015


    • 3 Tesla
    • MR imaging
    • Optic nerve
    • T2 hypointensity

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Clinical Neurology


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