Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation

Pre-clinical and clinical tests

Emanuel Särchen, Irina Petrova, Yuriy Petrov, Donald Prough, Walter Neu, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

We developed an optoacoustic technique for noninvasive, accurate, and continuous monitoring of total hemoglobin concentration and venous oxyhemoglobin saturation by probing specific blood vessels. In this work we report the development and tests of novel, focused optoacoustic transducers that provide blood vessel probing with sub-millimeter lateral resolution. The focused transducers were incorporated in our highly portable, laser diode-based optoacoustic monitoring system for pre-clinical and clinical tests. Our studies demonstrated that: 1) the focused transducer response is linearly dependent on blood total hemoglobin concentration with a high correlation coefficient; and 2) the sub-millimeter lateral resolution provided higher specificity of blood vessel probing, in particular, for smaller blood vessels such as the radial artery (diameter 2-3 mm).

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7564
DOIs
StatePublished - 2010
EventPhotons Plus Ultrasound: Imaging and Sensing 2010 - San Francisco, CA, United States
Duration: Jan 24 2010Jan 26 2010

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2010
CountryUnited States
CitySan Francisco, CA
Period1/24/101/26/10

Fingerprint

oxyhemoglobin
Oxyhemoglobins
Photoacoustic effect
Hemoglobin
blood vessels
Blood vessels
hemoglobin
Transducers
Blood Vessels
transducers
Hemoglobins
saturation
Monitoring
Photoacoustic Techniques
Semiconductor Lasers
Radial Artery
arteries
correlation coefficients
blood
Semiconductor lasers

Keywords

  • Focused transducer
  • Noninvasive monitoring
  • Optoacoustics
  • Total hemoglobin concentration

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation : Pre-clinical and clinical tests. / Särchen, Emanuel; Petrova, Irina; Petrov, Yuriy; Prough, Donald; Neu, Walter; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7564 2010. 75641I.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Särchen, E, Petrova, I, Petrov, Y, Prough, D, Neu, W & Esenaliev, R 2010, Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation: Pre-clinical and clinical tests. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7564, 75641I, Photons Plus Ultrasound: Imaging and Sensing 2010, San Francisco, CA, United States, 1/24/10. https://doi.org/10.1117/12.847084
Särchen, Emanuel ; Petrova, Irina ; Petrov, Yuriy ; Prough, Donald ; Neu, Walter ; Esenaliev, Rinat. / Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation : Pre-clinical and clinical tests. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7564 2010.
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