Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation: Pre-clinical and clinical tests

Emanuel Särchen, Irina Petrova, Yuriy Petrov, Donald Prough, Walter Neu, Rinat O. Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

We developed an optoacoustic technique for noninvasive, accurate, and continuous monitoring of total hemoglobin concentration and venous oxyhemoglobin saturation by probing specific blood vessels. In this work we report the development and tests of novel, focused optoacoustic transducers that provide blood vessel probing with sub-millimeter lateral resolution. The focused transducers were incorporated in our highly portable, laser diode-based optoacoustic monitoring system for pre-clinical and clinical tests. Our studies demonstrated that: 1) the focused transducer response is linearly dependent on blood total hemoglobin concentration with a high correlation coefficient; and 2) the sub-millimeter lateral resolution provided higher specificity of blood vessel probing, in particular, for smaller blood vessels such as the radial artery (diameter 2-3 mm).

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2010
DOIs
StatePublished - May 3 2010
EventPhotons Plus Ultrasound: Imaging and Sensing 2010 - San Francisco, CA, United States
Duration: Jan 24 2010Jan 26 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7564
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2010
CountryUnited States
CitySan Francisco, CA
Period1/24/101/26/10

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Keywords

  • Focused transducer
  • Noninvasive monitoring
  • Optoacoustics
  • Total hemoglobin concentration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Särchen, E., Petrova, I., Petrov, Y., Prough, D., Neu, W., & Esenaliev, R. O. (2010). Novel focused optoacoustic transducers for accurate monitoring of total hemoglobin concentration and oxyhemoglobin saturation: Pre-clinical and clinical tests. In Photons Plus Ultrasound: Imaging and Sensing 2010 [75641I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7564). https://doi.org/10.1117/12.847084