Novel inhibitors complexed with glutamate dehydrogenase: Allosteric regulation by control of protein dynamics

Keyphrases

• Protein Dynamics 100%
• Allosteric Regulation 100%
• Novel Inhibitors 100%
• Glutamate Dehydrogenase 100%
• Hyperammonemia 20%
• GW5074 20%
• Hexachlorophene 20%
• Bithionol 20%
• Contraction Process 20%
• Insulin 10%
• Conformational Change 10%
• Hyperinsulinemia 10%
• Hyperinsulinism 10%
• 2-oxoglutarate 10%
• Oxidative Deamination 10%
• Animal Kingdom 10%
• NADP+ 10%
• Epigallocatechin Gallate 10%
• Green Tea Polyphenols 10%
• Epicatechin Gallate 10%
• Hexamer 10%
• L-glutamine 10%
• Interface Residues 10%
• Subunit Communication 10%
• Catalytic Cleft 10%
• Internal Cavity 10%
• Allosteric Inhibition 10%
• High-throughput Study 10%
• Drug Molecules 10%
• Aromatic Stacking Interactions 10%

Biochemistry, Genetics and Molecular Biology

• Allosteric Regulation 100%
• Protein Dynamics 100%
• Glutamate Dehydrogenase 100%
• Bithionol 20%
• Wild Type 10%
• Secretion (Process) 10%
• Enzyme 10%
• Conformational Change 10%
• Guanosine Triphosphate 10%
• Oxidative Deamination 10%
• Epicatechin Gallate 10%
• Epigallocatechin Gallate 10%
• Coenzyme 10%
• Glutamic Acid 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Glutamate Dehydrogenase 100%
• Hyperammonemia 20%
• 3 (3,5 Dibromo 4 Hydroxybenzylidene) 1,3 Dihydro 5 Iodo 2 Indolone 20%
• Hexachlorophene 20%
• Bithionol 20%
• Glutamic Acid 10%
• Dimer 10%
• Hyperinsulinemia 10%
• Guanosine Triphosphate 10%
• Epigallocatechin Gallate 10%
• Polyphenol 10%
• Epicatechin Gallate 10%
• Hyperinsulinism 10%
• 2 Oxoglutaric Acid 10%
• Diseases 10%