Novel optoacoustic system for noninvasive, continuous monitoring of cerebral venous blood oxygenation

Yuriy Petrov, Irene Y. Petrov, Donald Prough, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) and spinal cord injury are a major cause of death for individuals under 50 years of age. In the USA alone, 150,000 patients per year suffer moderate or severe TBI. Moreover, TBI is a major cause of combatrelated death. Monitoring of cerebral venous blood oxygenation is critically important for management of TBI patients because cerebral venous blood oxygenation below 50% results in death or severe neurologic complications. At present, there is no technique for noninvasive, accurate monitoring of this clinically important variable. We proposed to use optoacoustic technique for noninvasive monitoring of cerebral venous blood oxygenation by probing cerebral veins such as the superior sagittal sinus (SSS) and validated it in animal studies. In this work, we developed a novel, medical grade optoacoustic system for continuous, real-time cerebral venous blood oxygenation monitoring and tested it in human subjects at normal conditions and during hyperventilation to simulate changes that may occur in patients with TBI. We designed and built a highly-sensitive optoacoustic probe for SSS signal detection. Continuous measurements were performed in the near infrared spectral range and the SSS oxygenation absolute values were automatically calculated in real time using a special algorithm developed by our group. Continuous measurements performed at normal conditions and during hyperventilation demonstrated that hyperventilation resulted in approximately 12% decrease of cerebral venous blood oxygenation.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8223
DOIs
StatePublished - 2012
EventPhotons Plus Ultrasound: Imaging and Sensing 2012 - San Francisco, CA, United States
Duration: Jan 22 2012Jan 24 2012

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2012
CountryUnited States
CitySan Francisco, CA
Period1/22/121/24/12

Fingerprint

Oxygenation
brain damage
Photoacoustic effect
oxygenation
blood
hyperventilation
Superior Sagittal Sinus
Blood
Hyperventilation
Brain
sinuses
Monitoring
death
Photoacoustic Techniques
Cause of Death
Cerebral Veins
spinal cord injuries
Computer Systems
Spinal Cord Injuries
causes

Keywords

  • Cerebral blood saturation
  • Clinical applications
  • Imaging
  • Noninvasive monitoring
  • Optoacoustics

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, Y., Petrov, I. Y., Prough, D., & Esenaliev, R. (2012). Novel optoacoustic system for noninvasive, continuous monitoring of cerebral venous blood oxygenation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8223). [82231L] https://doi.org/10.1117/12.914650

Novel optoacoustic system for noninvasive, continuous monitoring of cerebral venous blood oxygenation. / Petrov, Yuriy; Petrov, Irene Y.; Prough, Donald; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8223 2012. 82231L.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, Y, Petrov, IY, Prough, D & Esenaliev, R 2012, Novel optoacoustic system for noninvasive, continuous monitoring of cerebral venous blood oxygenation. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8223, 82231L, Photons Plus Ultrasound: Imaging and Sensing 2012, San Francisco, CA, United States, 1/22/12. https://doi.org/10.1117/12.914650
Petrov Y, Petrov IY, Prough D, Esenaliev R. Novel optoacoustic system for noninvasive, continuous monitoring of cerebral venous blood oxygenation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8223. 2012. 82231L https://doi.org/10.1117/12.914650
Petrov, Yuriy ; Petrov, Irene Y. ; Prough, Donald ; Esenaliev, Rinat. / Novel optoacoustic system for noninvasive, continuous monitoring of cerebral venous blood oxygenation. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8223 2012.
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