Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

William Marciel de Souza, Marilia Farignoli Romeiro, Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Marcilio Jorge Fumagalli, Sejal Modha, Marcio Roberto Teixeira Nunes, Pablo Ramiro Murcia, Luiz Tadeu Moraes Figueiredo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalVirology
Volume519
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • Hepatitis E virus
  • Hepeviridae
  • Orthohepevirus
  • Rodent-borne viruses
  • Viral hepatitis

ASJC Scopus subject areas

  • Virology

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