Novel predictors of sepsis outperform the american burn association sepsis criteria in the burn intensive care unit patient

Elizabeth A. Mann-Salinas, Mara M. Baun, Janet C. Meininger, Clinton K. Murray, James K. Aden, Steven Wolf, Charles E. Wade

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The purpose of this study was to determine whether systemic inflammatory response syndrome (SIRS) and American Burn Association (ABA) criteria predict sepsis in the burn patient and develop a model representing the best combination of novel clinical sepsis predictors. A retrospective, case-controlled, within-patient comparison of burn patients admitted to a single intensive care unit from January 2005 to September 2010 was made. Blood culture results were paired with documented sepsis: positive-sick, negative-sick (collectively defined as sick), and negative-not sick. Data for all predictors were collected for the 72 hours before blood culture. Variables were evaluated using regression and area under the curve (AUC) analyses. Fifty-nine subjects represented 177 culture periods. SIRS criteria were not discriminative: 98% of the subjects met criteria. ABA sepsis criteria were different on the day before (P = .004). The six best-fit variables identified for the model included heart rate > 130 beats per min, mean arterial pressure < 60 mm Hg, base deficit <-6 mEq/L, temperature < 36 C, use of vasoactive medications, and glucose > 150 mg/dl. The model was significant in predicting positive-sick and sick, with an AUC of 0.775 (P < .001) and 0.714 (P < .001), respectively; comparatively, the ABA criteria AUC was 0.619 (P = .028) and 0.597 (P = .035), respectively. Usefulness of the ABA criteria to predict sepsis is limited to the day before blood culture is obtained. A significant contribution of this research is the identification of six novel sepsis predictors for the burn patient.

Original languageEnglish (US)
Pages (from-to)31-43
Number of pages13
JournalJournal of Burn Care and Research
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Intensive Care Units
Sepsis
Area Under Curve
Systemic Inflammatory Response Syndrome
Arterial Pressure
Heart Rate
Research
Blood Culture

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Novel predictors of sepsis outperform the american burn association sepsis criteria in the burn intensive care unit patient. / Mann-Salinas, Elizabeth A.; Baun, Mara M.; Meininger, Janet C.; Murray, Clinton K.; Aden, James K.; Wolf, Steven; Wade, Charles E.

In: Journal of Burn Care and Research, Vol. 34, No. 1, 01.01.2013, p. 31-43.

Research output: Contribution to journalArticle

Mann-Salinas, Elizabeth A. ; Baun, Mara M. ; Meininger, Janet C. ; Murray, Clinton K. ; Aden, James K. ; Wolf, Steven ; Wade, Charles E. / Novel predictors of sepsis outperform the american burn association sepsis criteria in the burn intensive care unit patient. In: Journal of Burn Care and Research. 2013 ; Vol. 34, No. 1. pp. 31-43.
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