Novel purinergic sensitivity develops in injured sensory axons following sciatic nerve transection in rat

Yong Chen, Yi Hong Zhang, Zhi Qi Zhao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Teased fibers were made from 153 spontaneous A afferents ending in sciatic nerve end neuromas of 3-14 days standing, 21 A afferents from intact sensory endings in the contralateral sciatic nerve, and 50 intact A afferents from the sciatic nerve in intact rats. Ninety-two percent of the injured fibers responded to adenosine 5′-triphosphate (ATP) (i.v.). However, few fibers from the contralateral nerve or nerves from intact animals responded to ATP. P2 receptor antagonist suramin or reactive blue 2 blocked the ATP-induced response in 76% of the fibers tested, whereas the P1 receptor antagonist aminophylline blocked the ATP-evoked effect in only 18% of the fibers tested. Sympathectomy did not affect the ATP-induced effects in injured axons. Close-arterial injection of ATP caused similar results as i.v. injection of ATP. The present study suggests that a novel purinergic sensitivity is developed at the injury site after sciatic nerve transection in rats, which may play a role in neuropathic pain under some conditions such as sympathetic activation.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalBrain Research
Volume911
Issue number2
DOIs
StatePublished - Aug 24 2001
Externally publishedYes

Fingerprint

Sciatic Nerve
Axons
Adenosine Triphosphate
Cibacron Blue F 3GA
Neuroma
Suramin
Aminophylline
Injections
Sympathectomy
Neuralgia
Nerve Fibers
Wounds and Injuries

Keywords

  • Adenosine triphosphate
  • Chemosensitivity
  • Nerve injury
  • Neuroma
  • Neuropathic pain
  • P2 receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Novel purinergic sensitivity develops in injured sensory axons following sciatic nerve transection in rat. / Chen, Yong; Zhang, Yi Hong; Zhao, Zhi Qi.

In: Brain Research, Vol. 911, No. 2, 24.08.2001, p. 168-172.

Research output: Contribution to journalArticle

Chen, Yong ; Zhang, Yi Hong ; Zhao, Zhi Qi. / Novel purinergic sensitivity develops in injured sensory axons following sciatic nerve transection in rat. In: Brain Research. 2001 ; Vol. 911, No. 2. pp. 168-172.
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