Novel purinergic sensitivity develops in injured sensory axons following sciatic nerve transection in rat

Yong Chen, Yi Hong Zhang, Zhi Qi Zhao

Research output: Contribution to journalArticle

11 Scopus citations


Teased fibers were made from 153 spontaneous A afferents ending in sciatic nerve end neuromas of 3-14 days standing, 21 A afferents from intact sensory endings in the contralateral sciatic nerve, and 50 intact A afferents from the sciatic nerve in intact rats. Ninety-two percent of the injured fibers responded to adenosine 5′-triphosphate (ATP) (i.v.). However, few fibers from the contralateral nerve or nerves from intact animals responded to ATP. P2 receptor antagonist suramin or reactive blue 2 blocked the ATP-induced response in 76% of the fibers tested, whereas the P1 receptor antagonist aminophylline blocked the ATP-evoked effect in only 18% of the fibers tested. Sympathectomy did not affect the ATP-induced effects in injured axons. Close-arterial injection of ATP caused similar results as i.v. injection of ATP. The present study suggests that a novel purinergic sensitivity is developed at the injury site after sciatic nerve transection in rats, which may play a role in neuropathic pain under some conditions such as sympathetic activation.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalBrain Research
Issue number2
StatePublished - Aug 24 2001
Externally publishedYes



  • Adenosine triphosphate
  • Chemosensitivity
  • Nerve injury
  • Neuroma
  • Neuropathic pain
  • P2 receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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