Novel small molecule inhibitors of PTP1B

M. V.V.V. Sekhar Reddy, G. Chakshusmathi, Lakshmi M. Narasu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Protein tyrosine phosphatase is a classical non receptor tyrosine phosphotase enzyme and is an important regulator in several signaling pathways including insulin and leptin. PTP1B is a negative regulator of insulin receptor (IR) which dephosphorylates tyrosine residues of Insulin Receptor tyrosine Kinase (IRK) domain and induces resistance to insulin sensitivity and obesity up on over expression of PTP1B. Thus PTP1B is a vital therapeutic target for Type II diabetes and developing a selective PTP1B inhibitor is an essential breakthrough in controlling the disease which has been afflicting 1/3rd of world population. We have identified few small molecule PTP1B inhibitors which have shown micro molar range inhibition by in vitro pNPP assay method.

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalInternational Journal of Pharma and Bio Sciences
Volume3
Issue number2
StatePublished - Apr 1 2012

Keywords

  • Ir: insulin receptor
  • Irk: insulin receptor kinase
  • Pnpp: Para Nitro Phenol Pyrophosphate

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Sekhar Reddy, M. V. V. V., Chakshusmathi, G., & Narasu, L. M. (2012). Novel small molecule inhibitors of PTP1B. International Journal of Pharma and Bio Sciences, 3(2), 412-417.