Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses

Keyphrases

• Picornavirus 100%
• Polymerase 100%
• Uridylylation 100%
• 5′-end 50%
• Active Sites 33%
• Poliovirus 33%
• Covalently Bound 16%
• Pregenomic RNA (pgRNA) 16%
• Infected Cells 16%
• Viral Proteins 16%
• Binding Site 16%
• Mutagenesis 16%
• 3' End 16%
• Positively Charged 16%
• Triphosphate 16%
• Poly(A) 16%
• Molecular Modeling 16%
• Side Chain 16%
• Conserved Residues 16%
• Metal Ions 16%
• Freeform 16%
• NMR Structure 16%
• Experimental Structure 16%
• Tyrosinate 16%
• Model Complex 16%
• Transphosphorylation 16%

Biochemistry, Genetics and Molecular Biology

• Polymerase 100%
• Picornaviridae 100%
• VPg 100%
• RNA 50%
• Active Site 33%
• Poliomyelitis Virus 33%
• Viral Protein 16%
• Mutagenesis 16%
• Binding Site 16%
• Molecular Model 16%
• Uridine Triphosphate 16%

Immunology and Microbiology

• Picornaviridae 100%
• VPg 100%
• Poliomyelitis Virus 33%
• Viral Protein 16%
• Mutagenesis 16%
• Binding Site 16%
• Molecular Model 16%