Novel T-Lymphocyte Population in Combined Immunodeficiency with Features of Graft-versus-Host Disease

Daniel P. Wirt, Edward G. Brooks, Smita Vaidya, Gary R. Klimpel, Thomas A. Waldmann, Randall M. Goldblum

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

THE diverse functions of T lymphocytes in the defense of the host are mediated by multiple subpopulations that are often classified by the pattern in which they express surface structures. Most mature, post-thymic T cells bear the alpha/beta form of the T-cell receptor for antigen (TCR α/β). These cells also bear either CD4 or CD8 — glycoproteins characteristic of the helper-inducer and suppressor-cytotoxic subpopulations, respectively. A minor subpopulation of circulating T cells bears an alternative, gamma/delta form of the T-cell receptor for antigen (TCR γ/δ), but most of these cells express neither CD4 nor CD8.1 Both TCR α/β and TCR…

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalNew England Journal of Medicine
Volume321
Issue number6
DOIs
StatePublished - Aug 10 1989

ASJC Scopus subject areas

  • Medicine(all)

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    Wirt, D. P., Brooks, E. G., Vaidya, S., Klimpel, G. R., Waldmann, T. A., & Goldblum, R. M. (1989). Novel T-Lymphocyte Population in Combined Immunodeficiency with Features of Graft-versus-Host Disease. New England Journal of Medicine, 321(6), 370-374. https://doi.org/10.1056/NEJM198908103210606