Novel treatments in optic pathway gliomas

Akash Maheshwari, Mohammad Pakravan, Chaow Charoenkijkajorn, Shannon J. Beres, Andrew G. Lee

Research output: Contribution to journalReview articlepeer-review


Optic pathway gliomas (OPG) are primary tumors of the optic nerve, chiasm, and/or tract that can be associated with neurofibromatosis type 1 (NF1). OPG generally have a benign histopathology, but a variable clinical course. Observation is generally recommended at initial diagnosis if vision is stable or normal for age, however, treatment may include chemotherapy, radiotherapy, or surgery in select cases. This manuscript reviews the literature on OPG with an emphasis on recent developments in treatment.

Original languageEnglish (US)
Article number992673
JournalFrontiers in Ophthalmology
StatePublished - 2022
Externally publishedYes


  • BRAF inhibitor
  • MEK inhibitor
  • bevacizumab
  • chemotherapy
  • immunotherapy
  • low grade glioma
  • optic pathway glioma
  • stereotactic radiation

ASJC Scopus subject areas

  • Ophthalmology


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