NTproBNP as a surrogate biomarker for early screening of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants. Study design: Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups. Statistical analyses included repeated measures analysis of variance and receiver operator curve (ROC) generation. Results: Infants in the BPD-PH and BPD group had significantly elevated NTproBNP levels as compared to the control group. ROC curves for NTproBNP at 28 weeks CGA provided a cut-point of 2329 pg/ml and 578.1 pg/ml for detection of BPD-PH and BPD, respectively. Conclusions: NTproBNP appears to be a good screening tool to determine the onset of BPD-PH as early as 28 weeks CGA.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Jul 6 2018

Fingerprint

Bronchopulmonary Dysplasia
Brain Natriuretic Peptide
Pulmonary Hypertension
Premature Infants
Biomarkers
Gestational Age
Birth Weight
Analysis of Variance
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

@article{09d60e06c03d4b9cb7deafeac1f6cc29,
title = "NTproBNP as a surrogate biomarker for early screening of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia",
abstract = "Objective: Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants. Study design: Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups. Statistical analyses included repeated measures analysis of variance and receiver operator curve (ROC) generation. Results: Infants in the BPD-PH and BPD group had significantly elevated NTproBNP levels as compared to the control group. ROC curves for NTproBNP at 28 weeks CGA provided a cut-point of 2329 pg/ml and 578.1 pg/ml for detection of BPD-PH and BPD, respectively. Conclusions: NTproBNP appears to be a good screening tool to determine the onset of BPD-PH as early as 28 weeks CGA.",
author = "Soham Dasgupta and Ashraf Aly and Michael Malloy and Anthony Okorodudu and Sunil Jain",
year = "2018",
month = "7",
day = "6",
doi = "10.1038/s41372-018-0164-1",
language = "English (US)",
pages = "1--6",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - NTproBNP as a surrogate biomarker for early screening of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia

AU - Dasgupta, Soham

AU - Aly, Ashraf

AU - Malloy, Michael

AU - Okorodudu, Anthony

AU - Jain, Sunil

PY - 2018/7/6

Y1 - 2018/7/6

N2 - Objective: Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants. Study design: Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups. Statistical analyses included repeated measures analysis of variance and receiver operator curve (ROC) generation. Results: Infants in the BPD-PH and BPD group had significantly elevated NTproBNP levels as compared to the control group. ROC curves for NTproBNP at 28 weeks CGA provided a cut-point of 2329 pg/ml and 578.1 pg/ml for detection of BPD-PH and BPD, respectively. Conclusions: NTproBNP appears to be a good screening tool to determine the onset of BPD-PH as early as 28 weeks CGA.

AB - Objective: Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants. Study design: Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups. Statistical analyses included repeated measures analysis of variance and receiver operator curve (ROC) generation. Results: Infants in the BPD-PH and BPD group had significantly elevated NTproBNP levels as compared to the control group. ROC curves for NTproBNP at 28 weeks CGA provided a cut-point of 2329 pg/ml and 578.1 pg/ml for detection of BPD-PH and BPD, respectively. Conclusions: NTproBNP appears to be a good screening tool to determine the onset of BPD-PH as early as 28 weeks CGA.

UR - http://www.scopus.com/inward/record.url?scp=85049585399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049585399&partnerID=8YFLogxK

U2 - 10.1038/s41372-018-0164-1

DO - 10.1038/s41372-018-0164-1

M3 - Article

AN - SCOPUS:85049585399

SP - 1

EP - 6

JO - Journal of Perinatology

JF - Journal of Perinatology

SN - 0743-8346

ER -