Nucleophilic Aromatic Substitution - Addition and Identification of an Amine

Steven W. Goldstein, Ashley Bill, Jyothi Dhuguru, Ola Ghoneim

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The addition of a nucleophilic functional group to an electron-deficient aromatic ring is a versatile reaction in the modern organic chemistry arsenal. The proper positioning of a leaving group on this ring effectively allows for a substitution reaction to occur. A 3 h laboratory experiment is described in which students utilize a common electrophilic aromatic ring and affect a substitution with an unknown amine, the identity of which is later characterized by the melting point and 1H NMR spectrum of the product.

Original languageEnglish (US)
Pages (from-to)1388-1390
Number of pages3
JournalJournal of Chemical Education
Volume94
Issue number9
DOIs
StatePublished - Sep 12 2017
Externally publishedYes

    Fingerprint

Keywords

  • Addition Reactions
  • Amines/Ammonium Compounds
  • Aromatic Compounds
  • Nucleophilic Substitution
  • Organic Chemistry
  • Problem Solving/Decision Making
  • Second-Year Undergraduate

ASJC Scopus subject areas

  • Chemistry(all)
  • Education

Cite this