Nucleotide sequence of the envelope protein gene of the tick-borne flavivirus, Kumlinge A52

J. E. Whitby, A. D. Jennings, Alan Barrett

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The envelope protein gene of the tick-borne flavivirus, Kumlinge A52, the prototype Finnish strain, has been amplified and sequenced.* The nucleotide and deduced amino acid sequence has been analyzed and compared with the closely related tick-borne encephalitis (TBE) virus, Western subtype, strain Neudoerfl, isolated in Austria. Although these two virus strains were isolated 12 years apart from different hosts and in different countries, the envelope proteins only differed by a single amino acid. It is likely, therefore, that strong selection pressures against antigenic variation exist. The possible reasons for this are discussed.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalVirus Genes
Volume7
Issue number2
DOIs
StatePublished - Jun 1993
Externally publishedYes

Fingerprint

Arthropod Proteins
Flavivirus
Tick-Borne Encephalitis Viruses
Antigenic Variation
Austria
Amino Acid Sequence
Proteins
Nucleotides
Viruses
Amino Acids
Pressure

Keywords

  • antigenic variation
  • envelope glycoprotein
  • flavivirus
  • tick-borne encephalitis

ASJC Scopus subject areas

  • Virology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

Cite this

Nucleotide sequence of the envelope protein gene of the tick-borne flavivirus, Kumlinge A52. / Whitby, J. E.; Jennings, A. D.; Barrett, Alan.

In: Virus Genes, Vol. 7, No. 2, 06.1993, p. 145-149.

Research output: Contribution to journalArticle

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