Nucleotide sequence of the envelope protein of a Turkish isolate of tick-borne encephalitis (TBE) virus is distinct from other viruses of the TBE virus complex

J. E. Whitby, S. N. Whitby, A. D. Jennings, J. R. Stephenson, Alan Barrett

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Turkish tick-borne encephalitis (TTE) virus causes an acute form of meningoencephalomyelitis in sheep in the north-western region of Turkey. The clinical syndrome resembles louping ill (LI) and the viruses responsible for both LI and TTE are members of the tick-borne encephalitis (TBE) complex of the Flaviviridae. The envelope protein gene of TTE virus was reverse-transcribed, amplified, cloned and sequenced. Alignment of the resultant sequence with those from other viruses of the TBE complex reveals that TTE virus is more closely related, at both nucleotide and amino acid levels (84.6% and 96% respectively), to the Central European (CEE) subtype of the TBE virus, usually associated with human disease. The relationship with LI virus is more distant (83 % and 93.5% respectively). These studies support the assertion that the ovine encephalomyelitis found in Turkey is caused by a virus that is genetically distinct from known strains of both LI and CEE viruses and from a number of other known viruses of the TBE complex.

Original languageEnglish (US)
Pages (from-to)921-924
Number of pages4
JournalJournal of General Virology
Volume74
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Tick-Borne Encephalitis Viruses
Viruses
Tick-Borne Encephalitis
Louping Ill
Proteins
Turkey
Visna
Flaviviridae
Sequence Alignment
Sheep
Nucleotides
Amino Acids

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Nucleotide sequence of the envelope protein of a Turkish isolate of tick-borne encephalitis (TBE) virus is distinct from other viruses of the TBE virus complex. / Whitby, J. E.; Whitby, S. N.; Jennings, A. D.; Stephenson, J. R.; Barrett, Alan.

In: Journal of General Virology, Vol. 74, No. 5, 1993, p. 921-924.

Research output: Contribution to journalArticle

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