NuMoM2b Sleep-Disordered Breathing study

Objectives and methods

Francesca L. Facco, Corette B. Parker, Uma M. Reddy, Robert M. Silver, Judette M. Louis, Robert C. Basner, Judith H. Chung, Frank P. Schubert, Grace W. Pien, Susan Redline, Daniel R. Mobley, Matthew A. Koch, Hyagriv N. Simhan, Chia Ling Nhan-Chang, Samuel Parry, William A. Grobman, David M. Haas, Deborah A. Wing, Brian M. Mercer, George Saade & 1 others Phyllis C. Zee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective The objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk factor for adverse pregnancy outcomes. Study Design NuMoM2b is a prospective cohort study of 10,037 nulliparous women with singleton gestations that was conducted across 8 sites with a central Data Coordinating and Analysis Center. The Sleep Disordered Breathing substudy recruited 3702 women from the cohort to undergo objective, overnight in-home assessments of sleep disordered breathing. A standardized level 3 home sleep test was performed between 6<sup>0</sup>-15<sup>0</sup> weeks' gestation (visit 1) and again between 22<sup>0</sup>-31<sup>0</sup> weeks' gestation (visit 3). Scoring of tests was conducted by a central Sleep Reading Center. Participants and their health care providers were notified if test results met "urgent referral" criteria that were based on threshold levels of apnea hypopnea indices, oxygen saturation levels, or electrocardiogram abnormalities but were not notified of test results otherwise. The primary pregnancy outcomes to be analyzed in relation to maternal sleep disordered breathing are preeclampsia, gestational hypertension, gestational diabetes mellitus, fetal growth restriction, and preterm birth. Results Objective data were obtained at visit 1 on 3261 women, which was 88.1% of the studies that were attempted and at visit 3 on 2511 women, which was 87.6% of the studies that were attempted. Basic characteristics of the substudy cohort are reported in this methods article. Conclusion The substudy was designed to address important questions regarding the relationship of sleep-disordered breathing on the risk of preeclampsia and other outcomes of relevance to maternal and child health.

Original languageEnglish (US)
Pages (from-to)542.e1-542.e127
JournalAmerican Journal of Obstetrics and Gynecology
Volume212
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Sleep Apnea Syndromes
Pregnancy Outcome
Pregnancy
Pre-Eclampsia
Sleep
Mothers
Pregnancy Induced Hypertension
Gestational Diabetes
Premature Birth
Apnea
Fetal Development
Health Personnel
Reading
Electrocardiography
Cohort Studies
Referral and Consultation
Outcome Assessment (Health Care)
Prospective Studies
Oxygen

Keywords

  • home sleep test
  • methods
  • pregnancy
  • sleep
  • sleep-disordered breathing

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Facco, F. L., Parker, C. B., Reddy, U. M., Silver, R. M., Louis, J. M., Basner, R. C., ... Zee, P. C. (2015). NuMoM2b Sleep-Disordered Breathing study: Objectives and methods. American Journal of Obstetrics and Gynecology, 212(4), 542.e1-542.e127. https://doi.org/10.1016/j.ajog.2015.01.021

NuMoM2b Sleep-Disordered Breathing study : Objectives and methods. / Facco, Francesca L.; Parker, Corette B.; Reddy, Uma M.; Silver, Robert M.; Louis, Judette M.; Basner, Robert C.; Chung, Judith H.; Schubert, Frank P.; Pien, Grace W.; Redline, Susan; Mobley, Daniel R.; Koch, Matthew A.; Simhan, Hyagriv N.; Nhan-Chang, Chia Ling; Parry, Samuel; Grobman, William A.; Haas, David M.; Wing, Deborah A.; Mercer, Brian M.; Saade, George; Zee, Phyllis C.

In: American Journal of Obstetrics and Gynecology, Vol. 212, No. 4, 01.04.2015, p. 542.e1-542.e127.

Research output: Contribution to journalArticle

Facco, FL, Parker, CB, Reddy, UM, Silver, RM, Louis, JM, Basner, RC, Chung, JH, Schubert, FP, Pien, GW, Redline, S, Mobley, DR, Koch, MA, Simhan, HN, Nhan-Chang, CL, Parry, S, Grobman, WA, Haas, DM, Wing, DA, Mercer, BM, Saade, G & Zee, PC 2015, 'NuMoM2b Sleep-Disordered Breathing study: Objectives and methods', American Journal of Obstetrics and Gynecology, vol. 212, no. 4, pp. 542.e1-542.e127. https://doi.org/10.1016/j.ajog.2015.01.021
Facco FL, Parker CB, Reddy UM, Silver RM, Louis JM, Basner RC et al. NuMoM2b Sleep-Disordered Breathing study: Objectives and methods. American Journal of Obstetrics and Gynecology. 2015 Apr 1;212(4):542.e1-542.e127. https://doi.org/10.1016/j.ajog.2015.01.021
Facco, Francesca L. ; Parker, Corette B. ; Reddy, Uma M. ; Silver, Robert M. ; Louis, Judette M. ; Basner, Robert C. ; Chung, Judith H. ; Schubert, Frank P. ; Pien, Grace W. ; Redline, Susan ; Mobley, Daniel R. ; Koch, Matthew A. ; Simhan, Hyagriv N. ; Nhan-Chang, Chia Ling ; Parry, Samuel ; Grobman, William A. ; Haas, David M. ; Wing, Deborah A. ; Mercer, Brian M. ; Saade, George ; Zee, Phyllis C. / NuMoM2b Sleep-Disordered Breathing study : Objectives and methods. In: American Journal of Obstetrics and Gynecology. 2015 ; Vol. 212, No. 4. pp. 542.e1-542.e127.
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AU - Silver, Robert M.

AU - Louis, Judette M.

AU - Basner, Robert C.

AU - Chung, Judith H.

AU - Schubert, Frank P.

AU - Pien, Grace W.

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AU - Mobley, Daniel R.

AU - Koch, Matthew A.

AU - Simhan, Hyagriv N.

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AU - Grobman, William A.

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AU - Wing, Deborah A.

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