Nutrition and shock in pediatric patients

M. A.Q. Curley, L. Castillo

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Critically ill patients, including those in shock, often present with significant metabolic derangement in protein and energy metabolism characterized by: increased protein breakdown which is not suppressed by protein or energy intake; reprioritization of protein synthesis with increased synthesis of acute-phase proteins; decreased synthesis of structural proteins; and high protein turnover. In addition, there is also glucose and lipid intolerance. Adequate nutritional and metabolic support of the critically ill child under these conditions is a challenging endeavor. Traditionally, critically ill children have received nutritional requirements based on those of healthy children despite the fact that the critically ill population is physiologically and metabolically different. Furthermore, nutritional requirements in healthy children are largely based on limited data. With emerging knowledge of non-nutritional functions of nutrients, adequacy of nutritional support and requirements will eventually depend on the goals to be achieved: nutritional, physiologic, and/or pharmacologic.

Original languageEnglish (US)
Pages (from-to)212-225
Number of pages14
JournalNew Horizons: Science and Practice of Acute Medicine
Issue number2
StatePublished - 1998
Externally publishedYes


  • Amino acid
  • Arginine
  • Critical illness
  • Nitric oxide
  • Nutrition
  • Pediatric

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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