Nutritional supplementation in monochorionic diamniotic twin pregnancies

Impact on twin-twin transfusion syndrome

Giuseppe Chiossi, Matthew R. Quigley, Emmanuel J. Esaka, Kristin Novic, Jennifer U. Celebrezze, Steven H. Golde, Ronald L. Thomas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Twin-to-twin transfusion syndrome (TTTS) has been related to unbalanced unidirectional arteriovenous anastomoses in the placenta of monochorionic diamniotic (DiMo) twin gestations. As maternal malnutrition accounting for hypoproteinemia and anemia has been detected in severe cases of TTTS, the purpose of this study was to evaluate the impact of early diet supplementation on TTTS. Fifty-one DiMo twin pregnancies were given commercially available oral nutritional diet supplements and then compared in a retrospective cohort study to 52 twin gestations with the same chorionicity but not subjected to nutritional supplementation. Diet supplementation was associated with lower overall incidence of TTTS (20/52 versus 8/51, p = 0.02) and with lower prevalence of TTTS at delivery (18/52 versus 6/51, p = 0.012) when compared with no supplementation. Nutritional intervention also significantly prolonged the time between the diagnosis of TTTS and delivery (9.4±3.7 weeks versus 4.6±6.5 weeks; p = 0.014). The earlier nutritional regimen was introduced, the lesser chance of detecting TTTS (p = 0.001). Although not statistically significant, dietary intervention was also associated with lower Quintero stage, fewer invasive treatments, and lower twin birth weight discordance. Diet supplementation appears to counter maternal metabolic abnormalities in DiMo twin pregnancies and improve perinatal outcomes in TTTS when combined with the standard therapeutic options.

Original languageEnglish (US)
Pages (from-to)667-672
Number of pages6
JournalAmerican Journal of Perinatology
Volume25
Issue number10
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Fetofetal Transfusion
Twin Pregnancy
Diet
Mothers
Arteriovenous Anastomosis
Hypoproteinemia
Pregnancy
Birth Weight
Malnutrition
Placenta
Anemia
Cohort Studies
Retrospective Studies

Keywords

  • Diamniotic monochorionic twins
  • Nutritional supplementation
  • Pregnancy outcome
  • Twin-to-twin transfusion syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Chiossi, G., Quigley, M. R., Esaka, E. J., Novic, K., Celebrezze, J. U., Golde, S. H., & Thomas, R. L. (2008). Nutritional supplementation in monochorionic diamniotic twin pregnancies: Impact on twin-twin transfusion syndrome. American Journal of Perinatology, 25(10), 667-672. https://doi.org/10.1055/s-0028-1091400

Nutritional supplementation in monochorionic diamniotic twin pregnancies : Impact on twin-twin transfusion syndrome. / Chiossi, Giuseppe; Quigley, Matthew R.; Esaka, Emmanuel J.; Novic, Kristin; Celebrezze, Jennifer U.; Golde, Steven H.; Thomas, Ronald L.

In: American Journal of Perinatology, Vol. 25, No. 10, 11.2008, p. 667-672.

Research output: Contribution to journalArticle

Chiossi, G, Quigley, MR, Esaka, EJ, Novic, K, Celebrezze, JU, Golde, SH & Thomas, RL 2008, 'Nutritional supplementation in monochorionic diamniotic twin pregnancies: Impact on twin-twin transfusion syndrome', American Journal of Perinatology, vol. 25, no. 10, pp. 667-672. https://doi.org/10.1055/s-0028-1091400
Chiossi, Giuseppe ; Quigley, Matthew R. ; Esaka, Emmanuel J. ; Novic, Kristin ; Celebrezze, Jennifer U. ; Golde, Steven H. ; Thomas, Ronald L. / Nutritional supplementation in monochorionic diamniotic twin pregnancies : Impact on twin-twin transfusion syndrome. In: American Journal of Perinatology. 2008 ; Vol. 25, No. 10. pp. 667-672.
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