Abstract
Using NMR and stopped-flow fluorescence, this study reveals hidden dynamics of the transcription factor CREB bound to DNA. Before fully dissociating from DNA, CREB undergoes many cycles of microscopic dissociation and reassociation. The hidden rebinding dynamics allows competitor proteins to displace CREB efficiently, providing a mechanistic basis for facilitated dissociation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 18930-18933 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 62 |
| Issue number | 76 |
| DOIs | |
| State | Published - Sep 29 2026 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Catalysis
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Fingerprint
Dive into the research topics of 'Observation of hidden dynamics underlying facilitated dissociation of proteins from DNA'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS