Occult paroxysmal atrial fibrillation in non-cryptogenic ischemic stroke

Jeffrey M. Katz, Melissa S. Eng, Claire Carrazco, Anand V. Patel, Ram Jadonath, Michele Gribko, Rohan Arora, Richard B. Libman

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objective: To determine the prevalence and risk factors for paroxysmal atrial fibrillation (PAF) diagnosis in non- cryptogenic ischemic stroke (CIS) patients. Methods: In this pilot-prospective cohort study of non-CIS patients from September 2014 to September 2017, 53 patients were enrolled. 51/53 patients were implanted within 10 days of stroke onset with the Reveal LINQ insertable cardiac monitor and monitored until PAF detection or a minimum of 12 months. Inclusion required diagnosis of a non-AF stroke etiology, age ≥ 40, and either a virtual CHADS2 score ≥ 3 or ≥ 2 PAF-related comorbidities. Results: Over a median monitoring period of 398 days, PAF was detected in 6/51 (11.8%) patients and anticoagulation was initiated in 5/6 (83.3%). Median time to PAF detection was 87 days (range 0–356 days). Median longest PAF episode was 96 min (range 1 to 1122 min), and 4/6 had multiple PAF recordings. Mean left atrial volume index was significantly higher in PAF patients (31.0 vs. 23.2 cc/m2; p = 0.04). Conclusion: Long-term monitoring of non-CIS patients detected PAF in a clinically relevant proportion of patients, resulting in stroke prevention therapy optimization. Further study to confirm these findings and refine the subset that would benefit from long-term cardiac monitoring is warranted.

Original languageEnglish (US)
Pages (from-to)2237-2242
Number of pages6
JournalJournal of neurology
Volume265
Issue number10
DOIs
StatePublished - Oct 1 2018
Externally publishedYes

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Keywords

  • Atrial fibrillation
  • Insertable cardiac monitor
  • Ischemic stroke
  • Risk factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Katz, J. M., Eng, M. S., Carrazco, C., Patel, A. V., Jadonath, R., Gribko, M., Arora, R., & Libman, R. B. (2018). Occult paroxysmal atrial fibrillation in non-cryptogenic ischemic stroke. Journal of neurology, 265(10), 2237-2242. https://doi.org/10.1007/s00415-018-8982-9