Oligodendrocytes in HIV-associated pain pathogenesis

Yuqiang Shi, Jianhong Shu, Zongsuo Liang, Subo Yuan, Shao-Jun Tang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Although the contributions of microglia and astrocytes to chronic pain pathogenesis have been a focal point of investigation in recent years, the potential role of oligodendrocytes, another major type of glial cells in the CNS that generates myelin, remains largely unknown. Results: We report here that cell markers of the oligodendrocyte lineage, including NG2, PDGFRα, and Olig2, are significantly increased in the spinal dorsal horn of HIV patients who developed chronic pain. The levels of myelin proteins myelin basic protein and proteolipid protein are also aberrant in the spinal dorsal horn of “pain-positive” HIV patients. Similarly, the oligodendrocyte and myelin markers are up-regulated in the spinal dorsal horn of a mouse model of HIV-1 gp120-induced pain. Surprisingly, the expression of gp120-induced mechanical allodynia appears intact up to 4 h after myelin basic protein is knocked down or knocked out. Conclusion: These findings suggest that oligodendrocytes are reactive during the pathogenesis of HIV-associated pain. However, interfering with myelination does not alter the induction of gp120-induced pain.

Original languageEnglish (US)
JournalMolecular Pain
Volume12
DOIs
StatePublished - Jun 1 2016

Fingerprint

Oligodendroglia
HIV
Pain
Myelin Basic Protein
Myelin Sheath
Chronic Pain
Proteolipids
Myelin Proteins
Hyperalgesia
Microglia
Neuroglia
Astrocytes
HIV-1
Spinal Cord Dorsal Horn
Proteins

Keywords

  • HIV-1 gp120
  • myelin
  • Oligodendrocyte
  • pain
  • spinal dorsal horn

ASJC Scopus subject areas

  • Molecular Medicine
  • Cellular and Molecular Neuroscience
  • Anesthesiology and Pain Medicine

Cite this

Oligodendrocytes in HIV-associated pain pathogenesis. / Shi, Yuqiang; Shu, Jianhong; Liang, Zongsuo; Yuan, Subo; Tang, Shao-Jun.

In: Molecular Pain, Vol. 12, 01.06.2016.

Research output: Contribution to journalArticle

Shi, Yuqiang ; Shu, Jianhong ; Liang, Zongsuo ; Yuan, Subo ; Tang, Shao-Jun. / Oligodendrocytes in HIV-associated pain pathogenesis. In: Molecular Pain. 2016 ; Vol. 12.
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