@article{57a12e8e84e147ecac0b31e2e44d47fa,
title = "Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain",
abstract = "We examined the ultrastructural localization of oligomeric proteins, Aβ42, and flotillin-1 in Tg2576 mouse brains by triple immunoelectron microscopy. Oligomer-specific immunoreactions localized to cell processes, especially to axon terminals with higher density in Tg than in nonTg mouse brains. The oligomer was less frequently colocalized to flotillin-1- immunoreactive rafts than Aβ42, suggesting that rafts are one of the sites of polymeric Aβ deposition, but not of oligomeric proteins including Aβ.",
keywords = "Alzheimer's disease, Amyloid-β, Flotillin-1, Oligomer, Raft, Tg2576 mouse",
author = "Hideko Kokubo and Rakez Kayed and Glabe, {Charles G.} and Saido, {Takaomi C.} and Nobuhisa Iwata and Helms, {J. Bernd} and Haruyasu Yamaguchi",
note = "Funding Information: The authors thank Dr. Karen Hsiao-Ashe (Department of Neurology, University of Minnesota) for kindly providing Tg2576 mice. The authors also thank R. Shinohara for technical assistance. HK also thanks Dr. M. Takatama and senior physical therapists in Geriatrics Research Institute Hospital for generous support. H. Yamaguchi was supported by a Grant-in-Aid for Scientific Research and that for Priority Areas from the Ministry of Education, Science, Sports, Culture and Technology, Japan, and Life Science Research Foundation of Japan.",
year = "2005",
month = may,
day = "31",
doi = "10.1016/j.brainres.2005.03.017",
language = "English (US)",
volume = "1045",
pages = "224--228",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1-2",
}