Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model

Aline Haas de Mello, Rosiane de Bona Schraiber, Mariana Pereira de Souza Goldim, Khiany Mathias, Carolini Mendes, Maria Eduarda Anastácio Borges Corrêa, Maria Luiza Gomes, Paulo Cesar Lock Silveira, Patrícia Fernanda Schuck, Fabricia Petronilho, Gislaine Tezza Rezin

Research output: Contribution to journalArticle

Abstract

This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg·(kg body mass)−1·day−1 of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.

Original languageEnglish (US)
Pages (from-to)693-701
Number of pages9
JournalBiochemistry and Cell Biology
Volume97
Issue number6
DOIs
StatePublished - Jan 1 2019

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Intra-Abdominal Fat
Omega-3 Fatty Acids
Nutrition
Unsaturated Fatty Acids
Obesity
Fats
Diet
High Fat Diet
Energy Intake
Obese Mice
Citric Acid Cycle
Fish Oils
Electron Transport
Energy Metabolism
Oxidative Stress
Oxidative stress
Antioxidants
Control Groups
Animals

Keywords

  • Energy metabolism
  • Obesity
  • Omega-3 PUFAs
  • Oxidative stress
  • Visceral fat

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

de Mello, A. H., Schraiber, R. D. B., Goldim, M. P. D. S., Mathias, K., Mendes, C., Corrêa, M. E. A. B., ... Rezin, G. T. (2019). Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model. Biochemistry and Cell Biology, 97(6), 693-701. https://doi.org/10.1139/bcb-2018-0361

Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model. / de Mello, Aline Haas; Schraiber, Rosiane de Bona; Goldim, Mariana Pereira de Souza; Mathias, Khiany; Mendes, Carolini; Corrêa, Maria Eduarda Anastácio Borges; Gomes, Maria Luiza; Silveira, Paulo Cesar Lock; Schuck, Patrícia Fernanda; Petronilho, Fabricia; Rezin, Gislaine Tezza.

In: Biochemistry and Cell Biology, Vol. 97, No. 6, 01.01.2019, p. 693-701.

Research output: Contribution to journalArticle

de Mello, AH, Schraiber, RDB, Goldim, MPDS, Mathias, K, Mendes, C, Corrêa, MEAB, Gomes, ML, Silveira, PCL, Schuck, PF, Petronilho, F & Rezin, GT 2019, 'Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model', Biochemistry and Cell Biology, vol. 97, no. 6, pp. 693-701. https://doi.org/10.1139/bcb-2018-0361
de Mello, Aline Haas ; Schraiber, Rosiane de Bona ; Goldim, Mariana Pereira de Souza ; Mathias, Khiany ; Mendes, Carolini ; Corrêa, Maria Eduarda Anastácio Borges ; Gomes, Maria Luiza ; Silveira, Paulo Cesar Lock ; Schuck, Patrícia Fernanda ; Petronilho, Fabricia ; Rezin, Gislaine Tezza. / Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model. In: Biochemistry and Cell Biology. 2019 ; Vol. 97, No. 6. pp. 693-701.
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AU - Mendes, Carolini

AU - Corrêa, Maria Eduarda Anastácio Borges

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AU - Silveira, Paulo Cesar Lock

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