Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model

Aline Haas de Mello, Rosiane de Bona Schraiber, Mariana Pereira de Souza Goldim, Khiany Mathias, Carolini Mendes, Maria Eduarda Anastácio Borges Corrêa, Maria Luiza Gomes, Paulo Cesar Lock Silveira, Patrícia Fernanda Schuck, Fabricia Petronilho, Gislaine Tezza Rezin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg·(kg body mass)−1·day−1 of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.

Original languageEnglish (US)
Pages (from-to)693-701
Number of pages9
JournalBiochemistry and Cell Biology
Issue number6
StatePublished - 2019
Externally publishedYes


  • Energy metabolism
  • Obesity
  • Omega-3 PUFAs
  • Oxidative stress
  • Visceral fat

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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