On the negative staining of the protein crystal structure

M. B. Sherman, E. V. Orlova, S. S. Terzyan, R. Kleine, N. A. Kiselev

Research output: Contribution to journalArticle

13 Scopus citations


It has been shown that in some cases negative staining reveals structure with details down to 0.4 nm in size, the nature of a protein playing a key role. Various stains seem to interact with different parts of a thermitase (a serine protease) molecule, which results in intensity changes in electron diffraction patterns.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
Issue number2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Instrumentation

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    Sherman, M. B., Orlova, E. V., Terzyan, S. S., Kleine, R., & Kiselev, N. A. (1981). On the negative staining of the protein crystal structure. Ultramicroscopy, 7(2), 131-137. https://doi.org/10.1016/0304-3991(81)90002-4