Oncocytoma in melanocytoma of the spinal cord

Case report

Benjamin Gelman, Todd T. Trier, Greg Chaljub, Joanna Borokowski, Haring J W Nauta

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE AND IMPORTANCE: Oncocytoma in the central nervous system is extremely unusual. The first reported example of oncocytoma in a melanocytoma of the spinal cord was successfully excised, and its pathological appearance is described. CLINICAL PRESENTATION: A 71-year-old woman presented with a 25-year history of back pain and myelographic evidence of a lumbar spinal cord mass. After declining surgical treatment for two decades, she elected eventually to have the mass excised. Preoperative magnetic resonance imaging revealed a large intraspinal mass that spanned spinal levels L3 through 51. TECHNIQUE: The mass was excised en bloc through posterior laminectomies, and histopathological analysis revealed a benign neoplasm composed predominantly of monotonous sheets of plump oncocytes. Electron microscopy confirmed that the cytoplasm of the oncocytes was packed full of mitochondria. Focal areas of the tumor contained spindle cells, with abundant intracytoplasmic granular deposits of brown melanin pigment that contained melanosomes. Positive Fontana-Masson, HMB-45, and S-100 staining confirmed the final diagnosis of melanocytoma, oncocytic variant. CONCLUSION: The first reported case of oncocytoma arising in spinal melanocytoma is described. After surgical excision, the patient recovered completely and has remained free of symptoms for 4 years.

Original languageEnglish (US)
Pages (from-to)756-759
Number of pages4
JournalNeurosurgery
Volume47
Issue number3
StatePublished - 2000

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Oxyphilic Adenoma
Oxyphil Cells
Spinal Cord
Melanosomes
Laminectomy
Melanins
Back Pain
Neoplasms
Electron Microscopy
Mitochondria
Cytoplasm
Central Nervous System
Magnetic Resonance Imaging
Staining and Labeling
Therapeutics

Keywords

  • Melanocytoma
  • Mitochondria
  • Neural crest
  • Oncocytoma
  • Schwannoma
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Gelman, B., Trier, T. T., Chaljub, G., Borokowski, J., & Nauta, H. J. W. (2000). Oncocytoma in melanocytoma of the spinal cord: Case report. Neurosurgery, 47(3), 756-759.

Oncocytoma in melanocytoma of the spinal cord : Case report. / Gelman, Benjamin; Trier, Todd T.; Chaljub, Greg; Borokowski, Joanna; Nauta, Haring J W.

In: Neurosurgery, Vol. 47, No. 3, 2000, p. 756-759.

Research output: Contribution to journalArticle

Gelman, B, Trier, TT, Chaljub, G, Borokowski, J & Nauta, HJW 2000, 'Oncocytoma in melanocytoma of the spinal cord: Case report', Neurosurgery, vol. 47, no. 3, pp. 756-759.
Gelman B, Trier TT, Chaljub G, Borokowski J, Nauta HJW. Oncocytoma in melanocytoma of the spinal cord: Case report. Neurosurgery. 2000;47(3):756-759.
Gelman, Benjamin ; Trier, Todd T. ; Chaljub, Greg ; Borokowski, Joanna ; Nauta, Haring J W. / Oncocytoma in melanocytoma of the spinal cord : Case report. In: Neurosurgery. 2000 ; Vol. 47, No. 3. pp. 756-759.
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